ArticleMolecular and biochemical parasitology2009
Two novel nucleobase/pentamidine transporters from Trypanosoma brucei.
Article in Molecular and biochemical parasitology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence.Interdisciplinary perspectives on infectious diseases · 2026Review
- Genetic disruption of nucleoside transporter 4 reveals its critical roles in malaria parasite sporozoite functions.Pathogens and global health · 2023Article
- Cloning and Characterization ofInternational journal of molecular sciences · 2023Article
- Synthesis and biological evaluation of imidamide analogs as selective anti-trypanosomal agents.Bioorganic & medicinal chemistry · 2022Article
- Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei.PloS one · 2017Article
- KHARON Is an Essential Cytoskeletal Protein Involved in the Trafficking of Flagellar Membrane Proteins and Cell Division in African Trypanosomes.The Journal of biological chemistry · 2016Article
- Characterization of a Novel Endoplasmic Reticulum Protein Involved in Tubercidin Resistance in Leishmania major.PLoS neglected tropical diseases · 2016Article
- GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.Molecular microbiology · 2015Article
- Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity.International journal for parasitology. Drugs and drug resistance · 2014Article
- Genetic dissection of drug resistance in trypanosomes.Parasitology · 2013Review
- Molecular identification and characterization of an essential pyruvate transporter from Trypanosoma brucei.The Journal of biological chemistry · 2013Article
- Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Nutrient transport and pathogenesis in selected parasitic protozoa.Eukaryotic cell · 2011Review
- Remodeling of protein and mRNA expression in Leishmania mexicana induced by deletion of glucose transporter genes.Molecular and biochemical parasitology · 2011Article
- Purine restriction induces pronounced translational upregulation of the NT1 adenosine/pyrimidine nucleoside transporter in Leishmania major.Molecular microbiology · 2010Article
- Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis.Antimicrobial agents and chemotherapy · 2010Article
- Transporters for drug delivery and as drug targets in parasitic protozoa.Clinical pharmacology and therapeutics · 2010Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
African trypanosomes are unable to synthesize purines de novo and must salvage preformed purine nucleosides and nucleobases from their hosts. The Trypanosoma brucei genome project has identified 12 members of the equilibrative nucleoside transporter family, most of which have been characterized previously as nucleoside and/or nucleobase transporters. Here the 11th member of this family, TbNT11.1, has been functionally expressed in null mutants of Leishmania that are deficient in purine nucleoside or nucleobase uptake and identified as a high-affinity purine nucleobase transporter. Expression of TbNT11.1 in Xenopus oocytes revealed that it is also a transporter for the diamidine drug pentamidine that is the principal drug employed to treat early stage human African trypanosomiasis and may thus contribute to the uptake of this therapeutically important compound. In addition, characterization of the 12th member of the family, TbNT12.1, reveals that it is an adenine/pentamidine transporter.
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