ArticleCancer genetics and cytogenetics2008
Amplification of the BP1 homeobox gene in breast cancer.
Article in Cancer genetics and cytogenetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis.Cellular & molecular biology letters · 2022Article
- Dlx5 and Dlx6 can antagonize cell division at the GBMC molecular and cell biology · 2019Article
- Homeoprotein DLX4 expression is increased in inflammatory breast cancer cases from an urban African-American population.Oncotarget · 2018Article
- DLX4 is associated with orofacial clefting and abnormal jaw development.Human molecular genetics · 2015Article
- The nuclear coactivator amplified in breast cancer 1 maintains tumor-initiating cells during development of ductal carcinoma in situ.Oncogene · 2014Article
- Increased copy number of the DLX4 homeobox gene in breast axillary lymph node metastasis.Cancer genetics · 2014Article
- NKL homeobox genes in leukemia.Leukemia · 2012Review
- The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro.Small GTPases · 2011Article
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Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
Abstract
The homeobox gene BP1 is expressed in over 80% of breast cancers and is associated with tumor progression and invasion. However, the mechanism of BP1 activation in these tumors remains unknown. Therefore our aim in this study is to assess the amplification status of the BP1 gene in breast cancer and to determine whether BP1 protein expression is caused by gene amplification in these tumors. BP1 amplification and expression were assessed in 36 samples. Twenty primary breast tumors (PBT) and 14 sentinel lymph node (SLN) metastases were analyzed using fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC), respectively. Because of the close proximity of BP1 and HER2/NEU genes on 17q, correlation between their amplification/expression was also investigated. Increased BP1 copy number was observed in 33% of the cases, with a frequency of 36% and 29% in the PBT and SLN metastasis, respectively. BP1 protein was expressed in 91% of the samples: in all of the PBT with increased BP1 copy number and 65% of PBT with normal copy number. HER2/NEU amplification was detected in 22% of the cases. Concordance between BP1 and HER2/NEU copy numbers was found in 68% of the PBT and 90% of the SLN metastasis. In conclusion, we demonstrated that the BP1 homeobox gene is amplified in breast cancer, both in PBT and SLN metastasis, with a significant correlation with HER2/NEU amplification. Considering that BP1 expression was observed in cases with both increased and normal BP1 copy number, we conclude that other mechanisms in addition to gene amplification play a role in BP1 protein expression.
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