Trial reportActa veterinaria Scandinavica2008
The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise.
Trial report in Acta veterinaria Scandinavica, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
- Trial
- Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.Animals : an open access journal from MDPI · 2025Article
- Effect of Regular Training on Platelet Function in Untrained Thoroughbreds.Animals : an open access journal from MDPI · 2024Article
- Evaluation of the Effects of an Undenatured Collagen Type-2-Based Nutraceutical (ARTHROSHINEAnimals : an open access journal from MDPI · 2024Article
- PCL and DMSOMaterials (Basel, Switzerland) · 2023Article
- Dietary Supplementation with Boswellia serrata, Verbascum thapsus, and Curcuma longa in Show Jumping Horses: Effects on Serum Proteome, Antioxidant Status, and Anti-Inflammatory Gene Expression.Life (Basel, Switzerland) · 2023Article
- Role of Dietary Methyl Sulfonyl Methane in Poultry.Animals : an open access journal from MDPI · 2023Review
- Effects of Dietary Organic and Inorganic Sulfur on Laying Performance, Egg Quality, Ileal Morphology, and Antioxidant Capacity in Laying Hens.Animals : an open access journal from MDPI · 2021Article
- Effects of methylsulfonylmethane on growth performance, immunity, antioxidant capacity, and meat quality in Pekin ducks.Poultry science · 2020Article
- Dietary methylsulfonylmethane supplementation and oxidative stress in broiler chickens.Poultry science · 2020Article
- Probiotic supplementation in trained trotter horses: effect on blood clinical pathology data and urine metabolomic assessed in field.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Viral, Serological, and Antioxidant Investigations of Equine Rhinitis A Virus in Serum and Nasal Swabs of Commercially Used Horses in Poland.BioMed research international · 2018Article
- Small Intestinal Absorption of Methylsulfonylmethane (MSM) and Accumulation of the Sulfur Moiety in Selected Tissues of Mice.Nutrients · 2017Article
- The preventive effects of two nutraceuticals on experimentally induced acute synovitis.Equine veterinary journal · 2017Article
- Review
- MSM ameliorates HIV-1 Tat induced neuronal oxidative stress via rebalance of the glutathione cycle.American journal of translational research · 2015Article
- Specialty supplement use and biologic measures of oxidative stress and DNA damage.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in mice.Inflammation · 2013Article
- Effect of Methylsulfonylmethane Pretreatment on Aceta-minophen Induced Hepatotoxicity in Rats.Iranian journal of basic medical sciences · 2013Article
- Effect of Carissa opaca leaves extract on lipid peroxidation, antioxidant activity and reproductive hormones in male rats.Lipids in health and disease · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExercise induces changes in several organs and tissues, and this process might be due to oxidative damage caused by free radicals and inflammatory mediators. Methyl Sulphonyl Methane, better known as MSM, is a naturally occurring sulphur compound with well-known antioxidant properties. On the other hand, Vitamin C is important in limiting free radical damage in the aqueous phase of the cell, and cellular vitamin C status may be linked to the mechanisms involved in quenching cellular reactive oxygen species. The aim of this study was to determine if supplementation with MSM and vitamin C could alleviate exercise-induced oxidative stress in horses undergoing jumping competition.
methodsTwenty four jumping horses involved in competition were used. Horses were given the following three treatment diets: control (without supplementation), MSM 8 mg/kg, and combined supplements (MSM 8 mg/kg + Vit-C 5 mg/kg). EDTA blood samples were collected before exercise, upon arrived to the schooling area (control), and each week after last show. Nitric oxide, carbon monoxide, lipid hydroperoxides and the antioxidant enzymes, glutathione peroxidase, glutathione transferase and glutathione reductase, plasma levels were determined.
resultsCompetition induced a significant increase in lipid peroxidation, nitric oxide and carbon monoxide. By contrary, reduced glutathione as well as antioxidant enzyme activities, were decreased. MSM administration significantly ameliorated all these exercise-related changes, and this effect was potentiated by Vit C reaching values in some of the parameters similar to those found before competition.
conclusionThese results suggest that jumping exercise could induce harmful effects on horses, probably due to an increase in oxidative damage and proinflammatory molecules. In addition, we have demonstrated that MSM could exert some protective effect on oxidative and inflammatory exercise-induced injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.