ArticleOral diseases2009
Transient TWEAK overexpression leads to a general salivary epithelial cell proliferation.
Article in Oral diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Tumor necrosis factor-like weak inducer of apoptosis and its potential roles in lupus nephritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Review
- Transgenic α-1-antitrypsin secreted into the bloodstream from salivary glands is biologically active.Oral diseases · 2011Article
- Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands.Oral diseases · 2010Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that has pro-apoptotic, pro-angiogenic and pro-inflammatory effects. In liver, TWEAK leads to proliferation of progenitor oval cells, but not of mature hepatocytes. This study evaluated the hypothesis that TWEAK overexpression in salivary glands would lead to the proliferation of a salivary progenitor cell.
methodsA recombinant, serotype 5 adenoviral vector encoding human TWEAK, AdhTWEAK, was constructed, initially tested in vitro, and then administered to male Balb/c mice via cannulation of Wharton's duct. TWEAK expression in vivo was monitored as protein secreted into saliva and serum by enzyme-linked immunosorbent assays. Salivary cell proliferation was monitored by proliferating cell nuclear antigen staining and apoptosis was monitored using TUNEL staining.
resultsAdhTWEAK administration led to a dose-dependent, transient TWEAK protein expression, detected primarily in saliva. Salivary epithelial cell proliferation was generalized, peaking on approximately days 2 and 3. TWEAK expression had no detectable effect on apoptosis of salivary epithelial cells.
conclusionTransient overexpression of TWEAK in murine salivary glands leads to a general proliferation of epithelial cells vs a selective stimulation of a salivary progenitor cell.
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Registered trials
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