ReviewAnnals of the New York Academy of Sciences2008
Nonhuman primate neuroimaging and the neurobiology of psychostimulant addiction.
Review in Annals of the New York Academy of Sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Quantification of dopamine transporter density with [18F]FECNT PET in healthy humans.Nuclear medicine and biology · 2014Trial
- Multimodal MRI Reveals Brain Structural Differences and Executive Dysfunction in Early Methamphetamine Abstinence.Brain and behavior · 2026Article
- Methamphetamine and Designer Stimulants Modulate Tonic Human Cerebrovascular Smooth Muscle Contractility: Relevance to Drug-Induced Neurovascular Stress.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Article
- Transcranial Stimulation for the Treatment of Stimulant Use Disorder.Neurology international · 2023Review
- Updated Perspectives on the Neurobiology of Substance Use Disorders Using Neuroimaging.Substance abuse and rehabilitation · 2023Review
- The acute toxic and neurotoxic effects of 3,4-methylenedioxymethamphetamine are more pronounced in adolescent than adult mice.Behavioural brain research · 2020Article
- The pharmacokinetics of 3-fluoroamphetamine following delivery using clinically relevant routes of administration.Drug delivery and translational research · 2020Article
- Nonhuman animal models of substance use disorders: Translational value and utility to basic science.Drug and alcohol dependence · 2020Review
- The synthetic cathinone psychostimulant α-PPP antagonizes serotonin 5-HTDrug testing and analysis · 2019Article
- A review of nonhuman primate models of early life stress and adolescent drug abuse.Neurobiology of stress · 2018Review
- Utility of Nonhuman Primates in Substance Use Disorders Research.ILAR journal · 2017Review
- The serotonin 5-HTJournal of psychopharmacology (Oxford, England) · 2017Review
- Long-Term Cognitive Functioning in Single-Dose Total-Body Gamma-Irradiated Rhesus Monkeys ( Macaca mulatta ).Radiation research · 2016Article
- Article
- Serotonin 2A receptors differentially contribute to abuse-related effects of cocaine and cocaine-induced nigrostriatal and mesolimbic dopamine overflow in nonhuman primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Contributions of neuroimaging to understanding sex differences in cocaine abuse.Experimental and clinical psychopharmacology · 2012Review
- Neuroimaging and drug taking in primates.Psychopharmacology · 2011Review
- Development of an apparatus and methodology for conducting functional magnetic resonance imaging (fMRI) with pharmacological stimuli in conscious rhesus monkeys.Journal of neuroscience methods · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neuroimaging techniques have led to significant advances in our understanding of the neurobiology and treatment of drug addiction in humans. The capability to conduct parallel studies in nonhuman primates and human subjects provides a powerful translational approach to link findings in human and animal research. A significant advantage of nonhuman primate models is the ability to use drug-naïve subjects in longitudinal designs that document the neurobiological changes that are associated with chronic drug use. Moreover, experimental therapeutics can be evaluated in subjects with well-documented histories of drug exposure. The in vivo distribution and pharmacokinetics of drug binding in brain have been related to the time-course of behavioral effects associated with the addictive properties of stimulants. Importantly, the characterization of drug interactions with specific protein targets in brain has identified potential targets for medication development. Neuroimaging has proven especially useful in studying the dynamic changes in neuronal function that may be associated with environmental variables. Last, neuroimaging has been used effectively in nonhuman primates to characterize both transient and long-lasting changes in brain chemistry associated with chronic drug exposure. Although there is some evidence to suggest neurotoxicity in humans with long histories of stimulant use, parallel studies in nonhuman primates have not identified consistent long-term changes in such neurochemical markers. Collectively, the results of these studies of nonhuman primates have enhanced our understanding of the neurobiological basis of stimulant addiction and should have a significant impact on efforts to develop medications to treat stimulant abuse.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.