ReviewCurrent medicinal chemistry2008
Recent advances in artemisinin production through heterologous expression.
Review in Current medicinal chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Safeguarding artemisinin: integrating bioproduction innovation and resistance management for malaria eradication.Malaria journal · 2025Review
- Comparison of phytochemical properties and expressional profiling of artemisinin synthesis-related genes in variousHeliyon · 2024Article
- Biosynthesis Investigations of Terpenoid, Alkaloid, and Flavonoid Antimicrobial Agents Derived from Medicinal Plants.Antibiotics (Basel, Switzerland) · 2022Review
- Assessment of Artemisinin Contents in SelectedMedicines (Basel, Switzerland) · 2019Article
- Biotechnological approaches for artemisinin production in Artemisia.World journal of microbiology & biotechnology · 2018Review
- Synthetic Strategies for Peroxide Ring Construction in Artemisinin.Molecules (Basel, Switzerland) · 2017Review
- Transgenic approach to increase artemisinin content in Artemisia annua L.Plant cell reports · 2014Review
- Potential ecological roles of artemisinin produced by Artemisia annua L.Journal of chemical ecology · 2014Review
- Article
- Plant community characteristics and their responses to environmental factors in the water level fluctuation zone of the three gorges reservoir in China.Environmental science and pollution research international · 2013Article
- Article
- An internal deletion in MTH1 enables growth on glucose of pyruvate-decarboxylase negative, non-fermentative Saccharomyces cerevisiae.Microbial cell factories · 2012Article
- Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts.Malaria research and treatment · 2012Article
- Arsenic-induced changes in morphological, physiological, and biochemical attributes and artemisinin biosynthesis in Artemisia annua, an antimalarial plant.Ecotoxicology (London, England) · 2011Article
- Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2011Article
- Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.In vitro cellular & developmental biology. Plant : journal of the Tissue Culture Association · 2011Article
- Methods and options for the heterologous production of complex natural products.Natural product reports · 2011Review
- Reproductive development modulates gene expression and metabolite levels with possible feedback inhibition of artemisinin in Artemisia annua.Plant physiology · 2010Article
- Biological actions of artemisinin: insights from medicinal chemistry studies.Molecules (Basel, Switzerland) · 2010Review
- In Vivo Antimalarial Effects of Iranian Flora Artemisia khorassanica against Plasmodium berghei and Pharmacochemistry of its Natural Components.Iranian journal of parasitology · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Artemisinin the sesquiterpene endoperoxide lactone extracted from the herb Artemisia annua, remains the basis for the current preferred treatment against the malaria parasite Plasmodium falciparum. In addition, artemisinin and its derivatives show additional anti-parasite, anti-cancer, and anti-viral properties. Widespread use of this valuable secondary metabolite has been hampered by low production in vivo and high cost of chemical synthesis in vitro. Novel production methods are required to accommodate the ever-growing need for this important drug. Past work has focused on increasing production through traditional breeding approaches, with limited success, and on engineering cultured plants for high production in bioreactors. New research is focusing on heterologous expression systems for this unique biochemical pathway. Recently discovered genes, including a cytochrome P450 and its associated reductase, have been shown to catalyze multiple steps in the biochemical pathway leading to artemisinin. This has the potential to make a semi-synthetic approach to production both possible and cost effective. Artemisinin precursor production in engineered Saccharomyces cerevisiae is about two orders of magnitude higher than from field-grown A. annua. Efforts to increase flux through engineered pathways are on-going in both E. coli and S. cerevisiae through combinations of engineering precursor pathways and downstream optimization of gene expression. This review will compare older approaches to overproduction of this important drug, and then focus on the results from the newer approaches using heterologous expression systems and how they might meet the demands for treating malaria and other diseases.
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Registered trials
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