ArticleAnnals of neurology2008
Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia.
Article in Annals of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 249 papers, 3 of them syntheses that pooled it.
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Who cites it
249 citing papers in PubMed, 3 syntheses or guidelines pooled it, 475 citations in OpenAlex.
- FDG-PET in the diagnosis of primary progressive aphasia: a systematic review.Annals of nuclear medicine · 2024Pooled it
- Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.Annals of neurology · 2018Pooled it
- Amyloid pet in primary progressive aphasia: case series and systematic review of the literature.Journal of neurology · 2017Pooled it
- Hemispheric Asymmetry of Neuroimaging Biomarkers in Early Onset Alzheimer's Disease: Clinical and Cognitive Outcomes.Annals of neurology · 2026Article
- The Adult Neurogenesis Theory of Alzheimer's Disease Predicts Where Tauopathy Develops in the Brain.International journal of molecular sciences · 2026Review
- Incidence of primary progressive aphasia in Salento, Italy: a population-based study.Alzheimer's research & therapy · 2026Article
- FDG-PET in the Evaluation of Primary Progressive Aphasia: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Musicality is Preserved in Neurodegeneration.The Yale journal of biology and medicine · 2026Review
- Mixed primary progressive aphasia and alcohol use disorder: a case of detailed clinical phenotyping outperforming molecular imaging.Neurocase · 2026Article
- Application of machine learning and temporal response function modeling of EEG data for differential diagnosis in primary progressive aphasia.Scientific reports · 2025Article
- Neuromodulation Interventions for Language Deficits in Alzheimer's Disease: Update on Current Practice and Future Developments.Brain sciences · 2025Review
- Physical phantom validation of clustering-initiated factorization in dynamic PET.Medical physics · 2025Article
- Use of Amyloid Positron-Emission Tomography to Diagnose Alzheimer's Disease in Clinical Practice in South Korea: Expert Recommendations.Journal of clinical neurology (Seoul, Korea) · 2025Review
- Multi-parametric [European journal of nuclear medicine and molecular imaging · 2025Article
- The Pattern of Phonological, Semantic, and Circumlocution Naming Errors for Nouns and Verbs in Primary Progressive Aphasia.Aphasiology · 2025Article
- Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer's disease.Brain, behavior, and immunity · 2024Article
- Baseline Conceptual-Semantic Impairment Predicts Longitudinal Treatment Effects for Anomia in Primary Progressive Aphasia and Alzheimer's Disease.Aphasiology · 2024Article
- Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer`s disease.medRxiv : the preprint server for health sciences · 2023Article
- Network anatomy in logopenic variant of primary progressive aphasia.Human brain mapping · 2023Article
- Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity.Neurobiology of aging · 2023Article
189 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveAlzheimer's disease (AD) is found at autopsy in up to one third of patients with primary progressive aphasia (PPA), but clinical features that predict AD pathology in PPA are not well defined. We studied the relationships between language presentation, Abeta amyloidosis, and glucose metabolism in three PPA variants using [11C]-Pittsburgh compound B ([11C]PIB) and [18F]-labeled fluorodeoxyglucose positron emission tomography ([18F]FDG-PET).
methodsPatients meeting PPA criteria (N = 15) were classified as logopenic aphasia (LPA), progressive nonfluent aphasia (PNFA), or semantic dementia (SD) based on language testing. [11C]PIB distribution volume ratios were calculated using Logan graphical analysis (cerebellar reference). [18F]FDG images were normalized to pons. Partial volume correction was applied.
resultsElevated cortical PIB (by visual inspection) was more common in LPA (4/4 patients) than in PNFA (1/6) and SD (1/5) (p < 0.02). In PIB-positive PPA, PIB uptake was diffuse and indistinguishable from the pattern in matched AD patients (n = 10). FDG patterns were focal and varied by PPA subtype, with left temporoparietal hypometabolism in LPA, left frontal hypometabolism in PNFA, and left anterior temporal hypometabolism in SD. FDG uptake was significant asymmetric (favoring left hypometabolism) in PPA (p < 0.005) but not in AD.
interpretationLPA is associated with Abeta amyloidosis, suggesting that subclassification of PPA based on language features can help predict the likelihood of AD pathology. Language phenotype in PPA is closely related to metabolic changes that are focal and anatomically distinct between subtypes, but not to amyloid deposition patterns that are diffuse and similar to AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.