ArticleEuropean journal of immunology2008
Endothelial Src kinase regulates membrane recycling from the lateral border recycling compartment during leukocyte transendothelial migration.
Article in European journal of immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Prostaglandin EThe American journal of pathology · 2026Article
- Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis.Immunity · 2023Article
- Review
- Paracellular and Transcellular Leukocytes Diapedesis Are Divergent but Interconnected Evolutionary Events.Genes · 2021Article
- 4D intravital microscopy uncovers critical strain differences for the roles of PECAM and CD99 in leukocyte diapedesis.American journal of physiology. Heart and circulatory physiology · 2016Article
- Transendothelial migration: unifying principles from the endothelial perspective.Immunological reviews · 2016Review
- Recent insights into endothelial control of leukocyte extravasation.Cellular and molecular life sciences : CMLS · 2016Review
- The regulation of transendothelial migration: new knowledge and new questions.Cardiovascular research · 2015Review
- Segregation of VE-cadherin from the LBRC depends on the ectodomain sequence required for homophilic adhesion.Journal of cell science · 2015Article
- Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation.Mediators of inflammation · 2015Review
- How endothelial cells regulate transmigration of leukocytes in the inflammatory response.The American journal of pathology · 2014Article
- Neutrophil and monocyte recruitment by PECAM, CD99, and other molecules via the LBRC.Seminars in immunopathology · 2014Review
- Article
- Mechanisms of leukocyte transendothelial migration.Annual review of pathology · 2011Review
- Breaching multiple barriers: leukocyte motility through venular walls and the interstitium.Nature reviews. Molecular cell biology · 2010Review
- Mechanisms of transendothelial migration of leukocytes.Circulation research · 2009Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
When leukocytes cross endothelial cells during the inflammatory response, membrane from the recently described lateral border recycling compartment (LBRC) is selectively targeted around diapedesing leukocytes. This "targeted recycling" is critical for leukocyte transendothelial migration. Blocking homophilic PECAM interactions between leukocytes and endothelial cells blocks targeted recycling from the LBRC and blocks diapedesis. However, the cellular signaling pathways that trigger targeted recycling are not known. We show that targeted recycling from the LBRC is dependent on Src kinase. The selective Src kinase inhibitor PP2 blocked targeted recycling and blocked diapedesis by over 70%. However, Src kinase inhibition did not affect the structure or normal constitutive recycling of membrane from the LBRC in the absence of leukocytes. PECAM, a Src kinase substrate, traffics between the LBRC and the endothelial surface at the cell border. However, virtually all of the PECAM in the cell that was phosphorylated on tyrosine residues was found in the LBRC. These findings demonstrate that Src kinase activity is critical for the targeted recycling of membrane from the LBRC to the site of transendothelial migration and that the PECAM in the LBRC is qualitatively different from the PECAM on the surface of endothelial cells.
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Registered trials
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