Trial reportInhalation toxicology2009
ECG parameters and exposure to carbon ultrafine particles in young healthy subjects.
Trial report in Inhalation toxicology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Short-term exposure to particulate matter on heart rate variability in humans: a systematic review of crossover and controlled studies.Environmental science and pollution research international · 2021Pooled it
- Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults.Particle and fibre toxicology · 2015Trial
- Inhalation of ultrafine carbon particles alters heart rate and heart rate variability in people with type 2 diabetes.Particle and fibre toxicology · 2014Trial
- Hidden danger: The long-term effect of ultrafine particles on mortality and its sociodemographic disparities in New York State.Journal of hazardous materials · 2024Article
- [Effects of ultrafine particulates on cardiac function in rat isolated heart].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Article
- Response of the Cardiac Autonomic Control to Exposure to Nanoparticles and Noise: A Cross-Sectional Study of Airport Ground Staff.International journal of environmental research and public health · 2021Article
- Low levels of fine particulate matter increase vascular damage and reduce pulmonary function in young healthy adults.Particle and fibre toxicology · 2020Article
- Acute effects of short-term exposure to air pollution while being physically active, the potential for modification: A review of the literature.Preventive medicine · 2020Review
- Heart rate variability and cardiac repolarization after exposure to zinc oxide nanoparticles in healthy adults.Journal of occupational medicine and toxicology (London, England) · 2020Article
- Ambient and controlled exposures to particulate air pollution and acute changes in heart rate variability and repolarization.Scientific reports · 2019Article
- Exposure to air pollution near a steel plant is associated with reduced heart rate variability: a randomised crossover study.Environmental health : a global access science source · 2017Article
- Evidence of Allergic Reactions and Cardiopulmonary Impairments among Traders Operating from Foodstuff Warehouses.BioMed research international · 2016Observational
- Elevated particle number concentrations induce immediate changes in heart rate variability: a panel study in individuals with impaired glucose metabolism or diabetes.Particle and fibre toxicology · 2015Article
- Ozone co-exposure modifies cardiac responses to fine and ultrafine ambient particulate matter in mice: concordance of electrocardiogram and mechanical responses.Particle and fibre toxicology · 2014Article
- Are ambient ultrafine, accumulation mode, and fine particles associated with adverse cardiac responses in patients undergoing cardiac rehabilitation?Environmental health perspectives · 2012Article
- Effects of exercise on systemic inflammatory, coagulatory, and cardiac autonomic parameters in an inhalational exposure study.Journal of occupational and environmental medicine · 2012Article
- Case report: supraventricular arrhythmia after exposure to concentrated ambient air pollution particles.Environmental health perspectives · 2012Article
- Psychological stress: a social pollutant that may enhance environmental risk.American journal of respiratory and critical care medicine · 2011Article
- Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors.Environmental health perspectives · 2010Article
- Changes in deceleration capacity of heart rate and heart rate variability induced by ambient air pollution in individuals with coronary artery disease.Particle and fibre toxicology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The mechanisms underlying the association between air pollution and cardiovascular morbidity and mortality are unknown. This study aimed to determine whether controlled exposure to elemental carbon ultrafine particles (UFP) affects electrocardiogram (ECG) parameters describing heart rate variability; repolarization duration, morphology, and variability; and changes in the ST segment. Two separate controlled studies (12 subjects each) were performed using a crossover design, in which each subject was exposed to filtered air and carbon UFP for 2 hours. The first protocol involved 2 exposures to air and 10 microg/m(3) (approximately 2 x 10(6) particles/cm(3), count median diameter approximately 25 nm, geometric standard deviation approximately 1.6), at rest. The second protocol included 3 exposures to air, 10, and 25 microg/m(3) UFP (approximately 7 x 10(6) particles/cm(3)), with repeated exercise. Each subject underwent a continuous digital 12-lead ECG Holter recording to analyze the above ECG parameters. Repeated measures analysis of variance (ANOVA) was used to compare tested parameters between exposures. The observed responses to UFP exposure were small and generally not significant, although there were trends indicating an increase in parasympathetic tone, which is most likely also responsible for trends toward ST elevation, blunted QTc shortening, and increased variability of T-wave complexity after exposure to UFP. Recovery from exercise showed a blunted response of the parasympathetic system after exposure to UFP in comparison to air exposure. In conclusion, transient exposure to 10-25 microg/m(3) ultrafine carbon particles does not cause marked changes in ECG-derived parameters in young healthy subjects. However, trends are observed indicating that some subjects might be susceptible to air pollution, with a response involving autonomic modulation of the heart and repolarization of the ventricular myocardium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.