ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2008
Survival after colorectal cancer diagnosis is associated with colorectal cancer family history.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Family history and the natural history of colorectal cancer: systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2015Pooled it
- Cohort profile: population-based cohorts of patients with colorectal cancer and of their relatives in Geneva, Switzerland.BMJ open · 2022Article
- Association between family history and prognosis of patients with colorectal cancer: a systematic review and meta-analysis.Translational cancer research · 2022Article
- Family history of colorectal cancer and survival: a Swedish population-based study.Journal of internal medicine · 2020Article
- Association of Family History With Cancer Recurrence, Survival, and the Incidence of Colorectal Adenoma in Patients With Colorectal Cancer.Journal of cancer prevention · 2019Article
- Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies.Cancer medicine · 2018Article
- Article
- Prognostic factors and survival of colorectal cancer in Kurdistan province, Iran: A population-based study (2009-2014).Medicine · 2017Observational
- Survival in familial colorectal cancer: a Danish cohort study.Familial cancer · 2015Article
- Observational
- Family history of colorectal cancer is not associated with colorectal cancer survival regardless of microsatellite instability status.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Family history of hepatocellulcar carcinoma is not associated with its patients' prognosis after hepatectomy.World journal of surgical oncology · 2013Article
- Prognostic impact of family history in southern Chinese patients with undifferentiated nasopharyngeal carcinoma.British journal of cancer · 2013Article
- A retrospective observational study of the relationship between family history and survival from colorectal cancer.British journal of cancer · 2013Article
- Article
- Meat consumption, ornithine decarboxylase gene polymorphism, and outcomes after colorectal cancer diagnosis.Journal of carcinogenesis · 2012Article
- Risk of second primary colorectal cancer among colorectal cancer cases: a population-based analysis.Journal of carcinogenesis · 2011Article
- Review
- Meat consumption, nonsteroidal anti-inflammatory drug use, and mortality among colorectal cancer patients in the California Teachers Study.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Nonsteroidal anti-inflammatory drugs: effects on mortality after colorectal cancer diagnosis.Cancer · 2009Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundColorectal cancer (CRC) family history is a known risk factor for CRC development; however, effects of CRC family history on survival after CRC diagnosis are less well-defined. Our population-based analysis investigates whether familial CRC cases exhibit improved survival compared with sporadic CRC cases.
methodsCases enrolled in the University of California Irvine Gene-Environment Study of Familial Colorectal Cancer from 1994 to 1996 were analyzed, with follow-up through December 2006. Cases were categorized as familial or sporadic based on self-reported CRC family history in a first-degree relative. Univariate and multivariate survival analyses with Cox proportional hazards ratios were done for overall survival (OS) and CRC-SS (CRC-SS).
resultsOne thousand one hundred fifty-four CRC cases were analyzed, including 781 colon cancer and 373 rectal cancer cases. Nineteen percent of colon cases had family history of CRC in a first-degree relative, compared with 16% of rectal cancer cases. No statistically significant differences between familial and sporadic colon or rectal cancer cases were detected for age, gender, ethnicity, stage, tumor location, histology, tumor grade, or stage-specific treatment rendered. Among colon cancer cases, family history of CRC (versus no family history as a reference group) was associated with improved OS (adjusted hazard ratio, 0.760; 95% confidence interval, 0.580-0.997), but not with CRC-SS (hazard ratio, 0.880; 95% confidence interval, 0.621-1.246). No OS or CRC-SS differences were detected for rectal cancer cases.
conclusionsCRC cases with family history of the disease have improved overall survival compared with sporadic CRC cases, a finding that is independent of other relevant clinical factors.
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