ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2009
Steady-state methadone blocks cocaine seeking and cocaine-induced gene expression alterations in the rat brain.
Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
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- Effects of rat strain and method of inducing ethanol drinking on Pavlovian-Instrumental-Transfer with ethanol-paired conditioned stimuli.Alcohol (Fayetteville, N.Y.) · 2019Article
- The role of neuronal nitric oxide synthase in cocaine place preference and mu opioid receptor expression in the nucleus accumbens.Psychopharmacology · 2018Article
- Conditioned stimuli's role in relapse: preclinical research on Pavlovian-Instrumental-Transfer.Psychopharmacology · 2016Review
- The opioid receptors as targets for drug abuse medication.British journal of pharmacology · 2015Review
- Fructose:glucose ratios--a study of sugar self-administration and associated neural and physiological responses in the rat.Nutrients · 2015Article
- Individual differences in gene expression of vasopressin, D2 receptor, POMC and orexin: vulnerability to relapse to heroin-seeking in rats.Physiology & behavior · 2015Article
- Effects of Venlafaxine & Methadone Alone and in Combination with Spontaneous Morphine withdrawal Syndrome & Pain Sensation in Rats.Basic and clinical neuroscience · 2015Article
- β-endorphin via the delta opioid receptor is a major factor in the incubation of cocaine craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Nitric oxide and histone deacetylases modulate cocaine-induced mu-opioid receptor levels in PC12 cells.BMC pharmacology & toxicology · 2012Article
- Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics.The Journal of clinical investigation · 2012Review
- The effects of acute and chronic steady state methadone on memory retrieval in rats.Psychopharmacology · 2012Article
- Treatment-like steady-state methadone in rats interferes with incubation of cocaine sensitization and associated alterations in gene expression.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2012Article
- Investigating Methamphetamine Craving Using the Extinction-Reinstatement Model in the Rat.Journal of addiction research & therapy · 2011Article
- Extreme marginalization: addiction and other mental health disorders, stigma, and imprisonment.Annals of the New York Academy of Sciences · 2011Review
- Opioid-dopamine interactions: implications for substance use disorders and their treatment.Biological psychiatry · 2010Article
- Identification of substance use and dependence among patients with viral hepatitis.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2010Article
- The role of hypocretin in driving arousal and goal-oriented behaviors.Brain research · 2010Review
- Drug-induced and genetic alterations in stress-responsive systems: Implications for specific addictive diseases.Brain research · 2010Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
To elucidate the effects of steady-state methadone exposure on responding to cocaine conditioned stimuli and on cocaine-induced alterations in central opioid, hypocretin/orexin, and D2 receptor systems, male Sprague-Dawley rats received intravenous infusions of 1 mg/kg/inf cocaine paired with an audiovisual stimulus over three days of conditioning. Then, mini pumps releasing vehicle or 30 mg/kg/day methadone were implanted (SC), and lever pressing for the stimulus was assessed in the absence of cocaine and after a cocaine prime (20 mg/kg, IP). It was found that rats treated with vehicle, but not methadone, responded for the cocaine conditioned stimulus and displayed elevated mu-opioid receptor mRNA expression in the nucleus accumbens core and basolateral amygdala, reduced hypocretin/orexin mRNA in the lateral hypothalamus, and reduced D2 receptor mRNA in the caudate-putamen. This is the first demonstration that steady-state methadone administered after cocaine exposure blocks cocaine-induced behavioral and neural adaptations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.