ArticlePsychiatry research2009
Profile of auditory information-processing deficits in schizophrenia.
Article in Psychiatry research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia.Schizophrenia research · 2018Pooled it
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- Timing is everything: neural response dynamics during syllable processing and its relation to higher-order cognition in schizophrenia and healthy comparison subjects.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2010Trial
- Sensory-gating deficit of the N100 mid-latency auditory evoked potential in medicated schizophrenia patients.Schizophrenia research · 2009Trial
- Attentional bias in paranoia: systematic review and meta-analysis.BJPsych open · 2026Review
- Enhancing cognitive control of our decisions: Making the most of humor during the IGT in females and males.Cognitive, affective & behavioral neuroscience · 2024Article
- Transcranial Alternating Current Stimulation Alters Auditory Steady-State Oscillatory Rhythms and Their Cross-Frequency Couplings.Clinical EEG and neuroscience · 2024Article
- P300 in schizophrenia: Then and now.Biological psychology · 2024Review
- The Use of Event-Related Potentials in the Study of Schizophrenia: An Overview.Advances in neurobiology · 2024Review
- Embedded figures in schizophrenia: A main deficit but no specificity.Schizophrenia research. Cognition · 2022Article
- Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium.Schizophrenia bulletin · 2022Article
- Mismatch Negativity and P3a Impairment through Different Phases of Schizophrenia and Their Association with Real-Life Functioning.Journal of clinical medicine · 2021Article
- Investigating the Relationships of P3b with Negative Symptoms and Neurocognition in Subjects with Chronic Schizophrenia.Brain sciences · 2021Article
- Timing dysfunction and cerebellar resting state functional connectivity abnormalities in youth at clinical high-risk for psychosis.Psychological medicine · 2021Article
- Deficits in attentional modulation of auditory N100 in first-episode schizophrenia.The European journal of neuroscience · 2021Article
- Tracing Links Between Early Auditory Information Processing and Negative Symptoms in Schizophrenia: An ERP Study.Frontiers in psychiatry · 2021Article
- P300 as an index of transition to psychosis and of remission: Data from a clinical high risk for psychosis study and review of literature.Schizophrenia research · 2020Review
- Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features.Biomarkers in neuropsychiatry · 2020Article
- Translational neurophysiological biomarkers of N-methyl-d-aspartate receptor dysfunction in serine racemase knockout mice.Biomarkers in neuropsychiatry · 2020Article
- Auditory Mismatch Negativity Under Predictive Coding Framework and Its Role in Psychotic Disorders.Frontiers in psychiatry · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Schizophrenia patients exhibit abnormalities in several different auditory event-related potential (ERP) measures. It is unclear how these abnormalities relate to each other, since multiple measures are rarely acquired from the same sample. This study addressed two related questions: 1) Are specific auditory ERP measures differentially impaired in schizophrenia? 2) Do abnormalities co-aggregate within the same patients? Nine auditory ERP measures were acquired in a single testing session from 23 schizophrenia patients and 22 healthy subjects. Hierarchical oblique factor analysis revealed that these measures aggregated into four factors, with each loading primarily on a single factor. Patient deficits were observed for two independent factors: N100/mismatch negativity (MMN) and P3a/P3b. N100/MMN abnormalities were associated with symptoms of alogia and formal thought disorder. P3a/P3b abnormalities were associated with avolition, attentional disturbances and delusions. We conclude that deficits in different ERP measures of early sensory processing at the level of the auditory cortex co-occur in patients. These likely represent a single differential deficit indexing the physiological abnormality underlying impaired language and verbal processing. This is relatively independent of a higher cortical deficit that mediates cognitive stimulus evaluation and underlies deficits in motivation, attention and reality testing. Such multidimensional profiling of ERP abnormalities may help to clarify the clinical and genetic heterogeneity of schizophrenia.
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