ArticleFertility and sterility2010
Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
Article in Fertility and sterility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
- The Association Between Heavy Metals Exposure and Sex Hormones: a Systematic Review on Current Evidence.Biological trace element research · 2022Pooled it
- Characterization of Carcinogenic and Non-Carcinogenic Metal(loid)s in Water Within a Uranium-Mining-Impacted Region in Northwestern New Mexico, USA.International journal of environmental research and public health · 2026Article
- Age-Dependent Effects of Heavy Metals on the Hypothalamic-Pituitary-Testicular Axis-Related Hormones in Men.Toxics · 2026Article
- Distinct Clusters of Testosterone Levels, Symptoms, and Serum Trace Elements in Young Men: A Cross-Sectional Analysis.Nutrients · 2025Article
- Association of Trace Elements with Polycystic Ovary Syndrome in Women-A Case-Control Study.Metabolites · 2025Article
- The Relationship Between Heavy Metals and Missed Abortion: Using Mediation of Serum Hormones.Biological trace element research · 2024Article
- Prosthetic Metals: Release, Metabolism and Toxicity.International journal of nanomedicine · 2024Review
- Impact of Cadmium and Lead Exposure on Camel Testicular Function: Environmental Contamination and Reproductive Health.Animals : an open access journal from MDPI · 2023Article
- Urinary Levels of 14 Metal Elements in General Population: A Region-Based Exploratory Study in China.Toxics · 2023Article
- The association between blood heavy metals level and sex hormones among postmenopausal women in the US.Frontiers in endocrinology · 2023Article
- Multi-omics signatures of the human early life exposome.Nature communications · 2022Article
- Metal(loid)s in Common Medicinal Plants in a Uranium Mining-Impacted Area in Northwestern New Mexico, USA.Plants (Basel, Switzerland) · 2022Article
- The effect of exposure to MoOScientific reports · 2022Article
- Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans.Communications biology · 2022Article
- Effects of Sub-Chronic Exposure to Imidacloprid on Reproductive Organs of Adult Male Rats: Antioxidant State, DNA Damage, and Levels of Essential Elements.Antioxidants (Basel, Switzerland) · 2021Article
- Review
- Performance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting.Environmental research · 2021Article
- Correlations between Basal Trace Minerals and Hormones in Middle and Long-Distance High-Level Male Runners.International journal of environmental research and public health · 2020Article
- In utero and peripubertal metals exposure in relation to reproductive hormones and sexual maturation and progression among boys in Mexico City.Environmental health : a global access science source · 2020Article
- External and Genetic Conditions Determining Male Infertility.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo explore associations between exposure to metals and male reproductive hormone levels.
designCross-sectional epidemiology study with adjustment for potential confounders.
settingUniversity Medical Center. PATIENT(S): Men recruited through two infertility clinics in Michigan. INTERVENTION(S): Metal concentrations and reproductive hormone levels were measured in blood samples collected from 219 men. MAIN OUTCOME MEASURE(S): Serum FSH, LH, inhibin B, T, and sex hormone-binding globulin levels. RESULT(S): Cadmium, copper, and lead were all significantly or suggestively positively associated with T when modeled individually, findings that are consistent with limited previous human and animal studies. Conversely, molybdenum was associated with reduced T. A significant inverse trend between molybdenum and T remained when additionally considering other metals in the model, and a positive association between T and zinc was also found. Finally, in exploratory analysis there was evidence for an interaction between molybdenum and zinc, whereby high molybdenum was associated with a 37% reduction in T (relative to the population median level) among men with low zinc. CONCLUSION(S): Although reductions in T and reproductive toxicity after molybdenum exposure have been previously demonstrated in animal studies, more research is needed to determine whether molybdenum poses a risk to human reproductive health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.