ArticleFertility and sterility2010
A potential role for colony-stimulating factor 1 in the genesis of the early endometriotic lesion.
Article in Fertility and sterility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models.Molecular human reproduction · 2025Pooled it
- The effectiveness of immunomodulatory therapies for patients with repeated implantation failure: a systematic review and network meta-analysis.Scientific reports · 2022Pooled it
- Embryo transfer strategy and therapeutic options in infertile patients with thin endometrium: a systematic review.Journal of assisted reproduction and genetics · 2019Pooled it
- A standardized protocol for autologous stromal vascular fraction therapy in refractory thin endometrium and a prospective single-arm clinical study.Stem cell research & therapy · 2026Article
- Novel therapeutic strategies for Asherman's syndrome: Endometrial regeneration using menstrual blood-derived stem cells.Regenerative therapy · 2025Review
- Endoscopic sleeve gastroplasty safety profile - retrospective, single-center analysis of 222 consecutive patients including the learning curve period.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024Article
- Cell-based therapy in thin endometrium and Asherman syndrome.Stem cell research & therapy · 2022Review
- Endometriosis in the Mouse: Challenges and Progress Toward a 'Best Fit' Murine Model.Frontiers in physiology · 2021Review
- Autocrine Production of Interleukin-34 Promotes the Development of Endometriosis through CSF1R/JAK3/STAT6 signaling.Scientific reports · 2019Article
- G-CSF and stem cell therapy for the treatment of refractory thin lining in assisted reproductive technology.Journal of assisted reproduction and genetics · 2017Review
- Co-culture with macrophages enhances the clonogenic and invasion activity of endometriotic stromal cells.Cell proliferation · 2017Article
- Whether G-CSF administration has beneficial effect on the outcome after assisted reproductive technology? A systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2016Article
- Estradiol is a critical mediator of macrophage-nerve cross talk in peritoneal endometriosis.The American journal of pathology · 2015Article
- Article
- Use of granulocyte colony-stimulating factor for the treatment of thin endometrium in experimental rats.PloS one · 2013Article
- Increased expression of macrophage colony-stimulating factor and its receptor in patients with endometriosis.Fertility and sterility · 2012Article
- Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells.Fertility and sterility · 2011Article
- Induction of endometrial epithelial cell invasion and c-fms expression by transforming growth factor beta.Molecular human reproduction · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the role(s) of colony-stimulating factor 1 (CSF-1) on the development of early endometriosis in a murine model by comparing rate of lesion formation in mice [1] homozygous for a CSF-1 mutation versus syngeneic controls and [2] after treatment with imatinib, a commercially available tyrosine kinase inhibitor that alters interaction(s) between CSF-1 and its receptor, c-fms.
designProspective, placebo-controlled animal study.
settingAcademic medical center. ANIMALS: Six- to 8-week old female FVB, wild-type C57BL/6, and CSF-1 op/op mice. INTERVENTION(S): Endometrial tissue from donor mice was used to induce endometriosis in murine recipients. In some experiments, mice homozygous for a CSF-1 mutation (CSF-1 op/op) were donors or recipients. In other experiments, donor and/or recipient mice received imatinib. MAIN OUTCOME MEASURE(S): Histologic confirmation of endometriosis, rate of lesion formation. RESULT(S): By 40 hours, recipient mice developed a mean of 7.2 +/- 0.9 endometriotic lesions that had invaded host surfaces, and mesothelial cells had proliferated over the entire surface of the implants. The CSF-1 op/op mice developed significantly fewer (mean 0.9 +/- 0.3) endometriotic lesions versus syngeneic controls. Imatinib treatment resulted in significantly fewer lesions when compared with sham-treated controls. CONCLUSION(S): Colony-stimulating factor 1 has a role in establishing early endometriotic lesions. Agents targeting CSF-1 or its actions have therapeutic potential for treating endometriosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.