ArticleBMC genetics2008
Polymorphisms of the IGF1R gene and their genetic effects on chicken early growth and carcass traits.
Article in BMC genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals.Animals : an open access journal from MDPI · 2021Review
- Unraveling genomic associations with feed efficiency and body weight traits in chickens through an integrative approach.BMC genetics · 2019Article
- Phytogenic compounds do not interfere physiological parameters and growth performances on two Indonesian local breeds of ducks.Veterinary world · 2019Article
- Analysis of Anasplatyrhynchos genome resequencing data reveals genetic signatures of artificial selection.PloS one · 2019Article
- Systematic transcriptome-wide analysis of mRNA-miRNA interactions reveals the involvement of miR-142-5p and its target (FOXO3) in skeletal muscle growth in chickens.Molecular genetics and genomics : MGG · 2018Article
- Genome-wide characterization of genetic variants and putative regions under selection in meat and egg-type chicken lines.BMC genomics · 2018Article
- Article
- Genome-wide expression profiling in muscle and subcutaneous fat of lambs in response to the intake of concentrate supplemented with vitamin E.BMC genomics · 2017Article
- Expression Profiles of IGF-1R Gene and Polymorphisms of its Regulatory Regions in Different Pig Breeds.The protein journal · 2016Article
- Deep Sequencing Analysis of miRNA Expression in Breast Muscle of Fast-Growing and Slow-Growing Broilers.International journal of molecular sciences · 2015Article
- Genome Scan for Selection in Structured Layer Chicken Populations Exploiting Linkage Disequilibrium Information.PloS one · 2015Article
- Associations of polymorphisms in GHRL, GHSR, and IGF1R genes with feed efficiency in chickens.Molecular biology reports · 2014Article
- Association between Motilin Receptor Gene Haplotypes and Growth Traits in Japanese Hinai-dori Crossbred Chickens.Asian-Australasian journal of animal sciences · 2014Article
- Overview of Genomic Insights into Chicken Growth Traits Based on Genome-Wide Association Study and microRNA Regulation.Current genomics · 2013Article
- Comparison of the genome-wide DNA methylation profiles between fast-growing and slow-growing broilers.PloS one · 2013Article
- Association between cholecystokinin type A receptor haplotypes and growth traits in Japanese Hinai-dori crossbred chickens.Molecular biology reports · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe insulin-like growth factor I receptor (IGF1R) has an important effect on growth, carcass, and meat quality traits in many species. However, few studies on associations of the IGF1R gene with growth and carcass traits have been reported in chickens. The objectives of the present study were to study the associations of the IGF1R gene with chicken early growth and carcass traits using a neutral test, variation scan of the gene, genetic diversity, linkage disequilibrium and association analyses.
resultsThe tree generated from the amino acid sequences of 15 species showed that the IGF1R gene was conservative in the whole evolution among the mammalian animals and chickens. In a total of 10,818 bp of sequence, 70 single nucleotide polymorphisms were identified in the chicken IGF1R gene. The allelic and genotypic frequency distribution, genetic diversity and linkage disequilibrium of 18 single nucleotide polymorphisms (SNPs) in the Xinghua and White Recessive Rock chickens showed that six of them were possibly associated with growth traits. Association analyses showed that the A17299834G SNP was significantly associated with chicken carcass body weight, eviscerated weight with giblets, eviscerated weight, body weights at 28, 35, and 56 d of age, leg length at 56 d of age, and daily weight gain at 0-4 weeks. The haplotypes of the A17307750G and A17307494G were associated with early growth traits. The haplotypes of the A17299834G and C17293932T were significantly associated with most of the early growth traits and carcass traits.
conclusionThere were rich polymorphisms in the chicken IGF1R gene. Several SNPs associated with chicken early growth traits and carcass traits were identified in the IGF1R gene by genetic diversity, linkage disequilibrium, and association analyses in the present study.
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