ArticleBMC cancer2008
Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study.
Article in BMC cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Eight functional polymorphisms in the estrogen receptor 1 gene and endometrial cancer risk: a meta-analysis.PloS one · 2013Pooled it
- Effect of isoflavone soy protein supplementation on endometrial thickness, hyperplasia, and endometrial cancer risk in postmenopausal women: a randomized controlled trial.Menopause (New York, N.Y.) · 2013Trial
- Genotype and Haplotype Analysis BetweenHealth science reports · 2025Article
- The rs2046210 Polymorphism Is Associated with Endometriosis Risk and Elevated Estrogen Receptor 1 Expression in the Eutopic Endometrium of Women with the Disease.Biomedicines · 2024Article
- Roles of estrogen receptor α in endometrial carcinoma (Review).Oncology letters · 2023Review
- Genetic Regulation of Physiological Reproductive Lifespan and Female Fertility.International journal of molecular sciences · 2021Review
- Characterization of immune pleiotropy of ESR1 gene in pigs.Immunogenetics · 2020Article
- Effect of Soy Isoflavone on Hot Flushes, Endometrial Thickness, and Breast Clinical as well as Sonographic Features.Iranian journal of public health · 2018Article
- Development of an AmpliSeqFrontiers in pharmacology · 2018Article
- Observational
- Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer.Endocrine-related cancer · 2015Article
- Potential mechanisms of an antiadenomyosis chinese herbal formula shaoyao-gancao decoction in primary cell culture model.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Estrogen receptors and human disease: an update.Archives of toxicology · 2012Review
- Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer.Cancer epidemiology · 2012Article
- Evaluation of functional genetic variants for breast cancer risk: results from the Shanghai breast cancer study.American journal of epidemiology · 2011Article
- Association of a single nucleotide polymorphism at 6q25.1,rs2046210, with endometrial cancer risk among Chinese women.Chinese journal of cancer · 2011Article
- Genetics talks to epigenetics? The interplay between sequence variants and chromatin structure.Current genomics · 2010Article
- Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes.Carcinogenesis · 2010Article
- Common genetic variability in ESR1 and EGF in relation to endometrial cancer risk and survival.British journal of cancer · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundEstrogen is an established endometrial carcinogen. One of the most important mediators of estrogenic action is the estrogen receptor alpha. We have investigated whether polymorphic variation in the estrogen receptor alpha gene (ESR1) is associated with endometrial cancer risk.
methodsIn 702 cases with invasive endometrial cancer and 1563 controls, we genotyped five markers in ESR1 and used logistic regression models to estimate odds ratios (OR) and 95 percent confidence intervals (CI).
resultsWe found an association between rs2234670, rs2234693, as well as rs9340799, markers in strong linkage disequilibrium (LD), and endometrial cancer risk. The association with rs9340799 was the strongest, OR 0.75 (CI 0.60-0.93) for heterozygous and OR 0.53 (CI 0.37-0.77) for homozygous rare compared to those homozygous for the most common allele. Haplotype models did not fit better to the data than single marker models.
conclusionWe found that intronic variation in ESR1 was associated with endometrial cancer risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.