ArticleBMC genomics2008
Gene expression profiling in chicken heterophils with Salmonella enteritidis stimulation using a chicken 44 K Agilent microarray.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Disentangling the innate immune responses of intestinal epithelial cells and lamina propria cells toFrontiers in microbiology · 2023Article
- Transcriptomic Analysis of the Spleen of Different Chicken Breeds Revealed the Differential Resistance ofGenes · 2022Article
- Examination of the Expression of Immunity Genes and Bacterial Profiles in the Caecum of Growing Chickens Infected withAnimals : an open access journal from MDPI · 2019Article
- Conserved, breed-dependent, and subline-dependent innate immune responses of Fayoumi and Leghorn chicken embryos to Newcastle disease virus infection.Scientific reports · 2019Article
- Highly multiplexed quantitative PCR-based platform for evaluation of chicken immune responses.PloS one · 2019Article
- Cecal CircRNAs Are Associated With the Response toFrontiers in immunology · 2019Article
- Messenger RNA Sequencing and Pathway Analysis Provide Novel Insights Into the Susceptibility toFrontiers in genetics · 2018Article
- The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens.BMC genomics · 2016Article
- Transcriptional and Bioinformatic Analysis Provide a Relationship between Host Response Changes to Marek's Disease Viruses Infection and an Integrated Long Terminal Repeat.Frontiers in cellular and infection microbiology · 2016Article
- Avian pathogenic Escherichia coli (APEC) infection alters bone marrow transcriptome in chickens.BMC genomics · 2015Article
- Critical Role of Glycogen Synthase Kinase-3β in Regulating the Avian Heterophil Response to Salmonella enterica Serovar Enteritidis.Frontiers in veterinary science · 2014Article
- Nuclear Factor kappa B is central to Marek's disease herpesvirus induced neoplastic transformation of CD30 expressing lymphocytes in-vivo.BMC systems biology · 2012Article
- A novel phage element of Salmonella enterica serovar Enteritidis P125109 contributes to accelerated type III secretion system 2-dependent early inflammation kinetics in a mouse colitis model.Infection and immunity · 2012Article
- Gene Expression Analysis of Toll-Like Receptor Pathways in Heterophils from Genetic Chicken Lines that Differ in Their Susceptibility to Salmonella enteritidis.Frontiers in genetics · 2012Article
- Leukocyte transcriptome from chickens infected with avian pathogenic Escherichia coli identifies pathways associated with resistance.Results in immunology · 2012Article
- Eukaryotic signaling pathways targeted by Salmonella effector protein AvrA in intestinal infection in vivo.BMC microbiology · 2010Article
- Global analysis of the eukaryotic pathways and networks regulated by Salmonella typhimurium in mouse intestinal infection in vivo.BMC genomics · 2010Article
- Article
- Genetic control of resistance to salmonellosis and to Salmonella carrier-state in fowl: a review.Genetics, selection, evolution : GSE · 2010Review
- Disruption of inducible 6-phosphofructo-2-kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSalmonella enterica serovar Enteritidis (SE) is one of the most common food-borne pathogens that cause human salmonellosis and usually results from the consumption of contaminated poultry products. The mechanism of SE resistance in chickens remains largely unknown. Previously, heterophils isolated from broilers with different genetic backgrounds (SE-resistant [line A] and -susceptible [line B]) have been shown to be important in defending against SE infections. To dissect the interplay between heterophils and SE infection, we utilized large-scale gene expression profiling.
resultsThe results showed more differentially expressed genes were found between different lines than between infection (SE-treated) and non-infection (control) samples within line. However, the numbers of expressed immune-related genes between these two comparisons were dramatically different. More genes related to immune function were down-regulated in line B than line A. The analysis of the immune-related genes indicated that SE infection induced a stronger, up-regulated gene expression of line heterophils A than line B, and these genes include several components in the Toll-like receptor (TLR) signaling pathway, and genes involved in T-helper cell activation.
conclusionWe found: (1) A divergent expression pattern of immune-related genes between lines of different genetic backgrounds. The higher expression of immune-related genes might be more beneficial to enhance host immunity in the resistant line; (2) a similar TLR regulatory network might exist in both lines, where a possible MyD88-independent pathway may participate in the regulation of host innate immunity; (3) the genes exclusively differentially expressed in line A or line B with SE infection provided strong candidates for further investigating SE resistance and susceptibility. These findings have laid the foundation for future studies of TLR pathway regulation and cellular modulation of SE infection in chickens.
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