ArticleMolecular microbiology2008
The diverse CheC-type phosphatases: chemotaxis and beyond.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Altering chemotaxis as a strategy to enhance the foraging range of motility-restricted bacteria.Communications biology · 2026Article
- Comparative insights into genome signatures of ferric iron oxide- and anode-stimulated Desulfuromonas spp. strains.BMC genomics · 2021Article
- Chemotaxis Towards Aromatic Compounds: Insights fromInternational journal of molecular sciences · 2019Review
- Organization of the Flagellar Switch Complex of Bacillus subtilis.Journal of bacteriology · 2019Article
- Assembly states of FliM and FliG within the flagellar switch complex.Journal of molecular biology · 2015Article
- Structure and activity of the flagellar rotor protein FliY: a member of the CheC phosphatase family.The Journal of biological chemistry · 2013Article
- The protein interaction network of a taxis signal transduction system in a halophilic archaeon.BMC microbiology · 2012Article
- The unique paradigm of spirochete motility and chemotaxis.Annual review of microbiology · 2012Review
- Article
- CheY3 of Borrelia burgdorferi is the key response regulator essential for chemotaxis and forms a long-lived phosphorylated intermediate.Journal of bacteriology · 2011Article
- Motility and chemotaxis in Campylobacter and Helicobacter .Annual review of microbiology · 2011Review
- Phosphorylation and dephosphorylation among Dif chemosensory proteins essential for exopolysaccharide regulation in Myxococcus xanthus.Journal of bacteriology · 2010Article
- A remote CheZ orthologue retains phosphatase function.Molecular microbiology · 2010Article
- Auxiliary phosphatases in two-component signal transduction.Current opinion in microbiology · 2010Review
- A predictive computational model of the kinetic mechanism of stimulus-induced transducer methylation and feedback regulation through CheY in archaeal phototaxis and chemotaxis.BMC systems biology · 2010Article
- Identical phosphatase mechanisms achieved through distinct modes of binding phosphoprotein substrate.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Functional analysis of the Helicobacter pylori flagellar switch proteins.Journal of bacteriology · 2009Article
- Motility and chemotaxis in alkaliphilic Bacillus species.Future microbiology · 2009Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A new class of protein phosphatases has emerged in the study of bacterial/archaeal chemotaxis, the CheC-type phosphatases. These proteins are distinct and unrelated to the well-known CheY-P phosphatase CheZ, though they have convergently evolved to dephosphorylate the same target. The family contains a common consensus sequence D/S-X(3)-E-X(2)-N-X(22)-P that defines the phosphatase active site, of which there are often two per protein. Three distinct subgroups make up the family: CheC, FliY and CheX. Further, the CheC subgroup can be divided into three classes. Bacillus subtilis CheC typifies the first class and might function as a regulator of CheD. Class II CheCs likely function as phosphatases in systems other than chemotaxis. Class III CheCs are found in the archaeal class Halobacteria and might function as class I CheCs. FliY is the main phosphatase in the B. subtilis chemotaxis system. CheX is quite divergent from the rest of the family, forms a dimer and some may function outside chemotaxis. A model for the evolution of the family is discussed.
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Registered trials
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