ArticleJournal of natural products2008
Molecular-targeted antitumor agents. 19. Furospongolide from a marine Lendenfeldia sp. sponge inhibits hypoxia-inducible factor-1 activation in breast tumor cells.
Article in Journal of natural products, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Marine life as a source of anti-prostate cancer agents: an updated overview (2003-2023).Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Marine-Derived Leads as Anticancer Candidates by Disrupting Hypoxic Signaling through Hypoxia-Inducible Factors Inhibition.Marine drugs · 2024Review
- Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review.Cancer metastasis reviews · 2024Review
- Scalarane-Type Sesterterpenoids from the Marine SpongeMarine drugs · 2021Article
- Identification of Bioactive Compounds from Marine Natural Products and Exploration of Structure-Activity Relationships (SAR).Antibiotics (Basel, Switzerland) · 2021Article
- Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents.Marine drugs · 2020Article
- Pharmacodynamic Functions of Synthetic Derivatives for Treatment of Methicillin-ResistantFrontiers in microbiology · 2020Article
- Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells.Marine drugs · 2015Article
- Antiproliferative homoscalarane sesterterpenes from two Madagascan sponges.Bioorganic & medicinal chemistry · 2013Article
- Dragon exploration system on marine sponge compounds interactions.Journal of cheminformatics · 2013Article
- Marine antitumor drugs: status, shortfalls and strategies.Marine drugs · 2010Review
- The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.Journal of natural products · 2009Article
- Lipophilic 2,5-disubstituted pyrroles from the marine sponge Mycale sp. inhibit mitochondrial respiration and HIF-1 activation.Journal of natural products · 2009Article
- Marine Natural Products as Inhibitors of Hypoxic Signaling in Tumors.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2009Article
- Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target.Journal of neuro-oncology · 2009Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A natural product chemistry-based approach was employed to discover small-molecule inhibitors of the important tumor-selective molecular target hypoxia-inducible factor-1 (HIF-1). Bioassay-guided isolation of an active lipid extract of a Saipan collection of the marine sponge Lendenfeldia sp. afforded the terpene-derived furanolipid furospongolide as the primary inhibitor of hypoxia-induced HIF-1 activation (IC(50) 2.9 μM, T47D breast tumor cells). The active component of the extract also contained one new cytotoxic scalarane sesterterpene and two previously reported scalaranes. Furospongolide blocked the induction of the downstream HIF-1 target secreted vascular endothelial growth factor (VEGF) and was shown to suppress HIF-1 activation by inhibiting the hypoxic induction of HIF-1α protein. Mechanistic studies indicate that furospongolide inhibits HIF-1 activity primarily by suppressing tumor cell respiration via the blockade of NADH-ubiquinone oxidoreductase (complex I)-mediated mitochondrial electron transfer.
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