ArticleEuropean journal of applied physiology2009
Regulation of mitochondrial respiration by inorganic phosphate; comparing permeabilized muscle fibers and isolated mitochondria prepared from type-1 and type-2 rat skeletal muscle.
Article in European journal of applied physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting.eLife · 2024Article
- Acanthamoeba castellanii phosphate transporter (AcPHS) is important to maintain inorganic phosphate influx and is related to trophozoite metabolic processes.Journal of bioenergetics and biomembranes · 2020Article
- Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.Scientific reports · 2020Article
- Regulation of autophagic and mitophagic flux during chronic contractile activity-induced muscle adaptations.Pflugers Archiv : European journal of physiology · 2019Article
- Differential Expression of NADPH Oxidases Depends on Skeletal Muscle Fiber Type in Rats.Oxidative medicine and cellular longevity · 2016Article
- Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Effect of high-fat diet on rat myometrium during pregnancy-isolated myometrial mitochondria are not affected.Pflugers Archiv : European journal of physiology · 2015Article
- Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake.The Journal of physiology · 2013Article
- Mitochondrial activation at the onset of contractions in isolated myofibres during successive contractile periods.The Journal of physiology · 2012Article
- Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy.Mitochondrion · 2012Article
- Article
- Isolation of functional mitochondria from rat kidney and skeletal muscle without manual homogenization.Analytical biochemistry · 2011Article
- Protein composition and function of red and white skeletal muscle mitochondria.American journal of physiology. Cell physiology · 2011Article
- Energetics of glucose metabolism: a phenomenological approach to metabolic network modeling.International journal of molecular sciences · 2010Article
- Mitochondrial base excision repair assays.Methods (San Diego, Calif.) · 2010Review
- Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- The O2 cost of the tension-time integral in isolated single myocytes during fatigue.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Application of the principles of systems biology and Wiener's cybernetics for analysis of regulation of energy fluxes in muscle cells in vivo.International journal of molecular sciences · 2010Review
- Intracellular diffusion restrictions in isolated cardiomyocytes from rainbow trout.BMC cell biology · 2009Article
- Multiple interaction partners for Cockayne syndrome proteins: implications for genome and transcriptome maintenance.Mechanisms of ageing and developmentReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ADP is generally accepted as a key regulator of oxygen consumption both in isolated mitochondria and in permeabilized fibers from skeletal muscle. The present study explored inorganic phosphate in a similar regulatory role. Saponin permeabilized fibers and isolated mitochondria from type-I and type-II muscle from male Wistar rats were prepared. Respiration was measured while the medium P(i) concentration was gradually increased. The apparent K(m) values for P(i) were 607 +/- 17 microM and 405 +/- 15 microM (P < 0.0001) for type-I and type-II fibers, respectively. For isolated mitochondria the values were significantly lower than type-1 permeabilized fibers, 338 +/- 130 microM and 235 +/- 30 microM (P < 0.05), but not different with respect to fiber type. The reason for this difference in K(m) values in the permeabilized muscle is unknown, but a similar pattern has been observed for K(m) of ADP. Our data indicate that phosphate may play a role in regulation of oxygen consumption in vitro and in vivo.
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