Evidence map›Paper›PMID 18989630›Full record

ReviewImmunologic research2009

Differential roles for the inositol phosphatase SHIP in the regulation of macrophages and lymphocytes.

Wai-Hang Leung, Tatyana Tarasenko, Silvia Bolland

Open access · greenAbstract readReview
In one paragraph

Review in Immunologic research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis.American journal of physiology. Gastrointestinal and liver physiology · 2017
    Article
  5. Article
  6. Article
  7. Review
  8. Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Wai-Hang LeungLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn drive, Twinbrook 2, Room 217, Rockville, MD 20852, USA.
Tatyana Tarasenko
Silvia Bolland
National Institute of Allergy and Infectious Diseases · USNational Institutes of Health · US

Funding

Regulation Of The Immune Response By The Inositol Phosphatase SHIPZIAAI000911 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BOLLAND, SILVIA · 2009 to 2010
$581k
Intramural NIH HHS ZIA AI000911
6 · The paper itself

Abstract

The SH2 domain-containing inositol 5'-phosphatase (SHIP) negatively regulates antigen, cytokine, and Fc receptor signaling pathways in immune cells. Our knowledge of the function of SHIP largely derives from in vitro studies that utilized SHIP-deficient cell lines and immune cells isolated from SHIP null mice. To avoid the pleiotropic effects observed in mice with germline deletion of SHIP, we have used the Cre-lox system to generate SHIP conditional knockout mice with deletion in specific immune cell populations. In this review we summarize our observations from mice with deletion of SHIP in lymphocyte and macrophage lineages and contrast them with earlier data gathered by the analysis of SHIP null mice.

Indexed as

AnimalsB-LymphocytesInositol Polyphosphate 5-PhosphatasesLymphocytesMacrophagesMiceMice, KnockoutPhosphoric Monoester HydrolasesReceptors, Antigen, B-CellReceptors, Antigen, T-CellT-Lymphocyte SubsetsInositol Polyphosphate 5-PhosphatasesPhosphoric Monoester HydrolasesReceptors, Antigen, B-CellReceptors, Antigen, T-Cell

Identifiers

PMID18989630
PMCPMC2807985
OpenAlexW2047321895

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.