ArticleActa histochemica et cytochemica2008
MeCP2 expression and promoter methylation of cyclin D1 gene are associated with cyclin D1 expression in developing rat epididymal duct.
Article in Acta histochemica et cytochemica, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Role of MeCP2 in Shaping the Histopathological Heterogeneity of Ampullary Carcinoma.Acta histochemica et cytochemica · 2026Article
- Roles of osteoclasts in pathological conditions.Pathology international · 2025Review
- Demethylation in promoter region of severely damaged hepatocytes enhances chemokine receptor CXCR4 gene expression.Histochemistry and cell biology · 2023Article
- Genomic mosaicism in the pathogenesis and inheritance of a Rett syndrome cohort.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Severe changes in colon epithelium in the Mecp2-null mouse model of Rett syndrome.Molecular and cellular pediatrics · 2016Article
- Reactivation of CDX2 in Gastric Cancer as Mark for Gene Silencing Memory.Acta histochemica et cytochemica · 2015Article
- DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution.Epigenetics & chromatin · 2014Article
- Expression of cysLT1 and cysLT2 receptor in chronic hyperplastic eosinophilic sinusitis.Acta histochemica et cytochemica · 2009Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypermethylation-dependent silencing of the gene is achieved by recruiting methyl-CpG binding proteins (MeCPs). Among the MeCPs, MeCP2 is the most abundantly and ubiquitously expressed in various types of cells. We first screened the distribution and expression pattern of MeCP2 in adult and developing rat tissues and found strong MeCP2 expression, albeit rather ubiquitously among normal tissues, in ganglion cells and intestinal epithelium in the small intestine, in Purkinje cells and neurons in the brain, in spermatogonia and in epithelial cells in the epididymal duct of the testis. We then assessed the expression and the methylation pattern of the promoter region of cyclin D1 by immunohistochemistry and sodium bisulfite mapping, and found that cyclin D1 expression in the epididymal duct decreased rapidly during rat development: strong in newborn rats and very weak or almost negative in 7-day-old rats. Mirroring the decrease of cyclin D1 expression, methylated cytosine at both CpG and non-CpG loci in the cyclin D1 promoter was frequently observed in the epididymal duct of 7-day-old rats but not in that of newborn rats. Interestingly, MeCP2 expression also increased concomitant with the increase of methylation. Cyclin D1 expression in the epididymal duct may be efficiently regulated by the epigenetic mechanism of the cooperative increase of MeCP2 expression and promoter methylation.
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