ArticlePLoS genetics2008
Silent but not static: accelerated base-pair substitution in silenced chromatin of budding yeasts.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
- The dynamics of loss of heterozygosity events in genomes.EMBO reports · 2025Review
- The Hsp90 Molecular Chaperone as a Global Modifier of the Genotype-Phenotype-Fitness Map: An Evolutionary Perspective.Journal of molecular biology · 2024Review
- Article
- Functional Diversification of Chromatin on Rapid Evolutionary Timescales.Annual review of genetics · 2021Review
- Chromatin Structure and Drug Resistance inJournal of fungi (Basel, Switzerland) · 2020Review
- The Telomere Paradox: Stable Genome Preservation with Rapidly Evolving Proteins.Trends in genetics : TIG · 2020Review
- An Evolutionary Perspective on Yeast Mating-Type Switching.Genetics · 2017Review
- Recurrent Innovation at Genes Required for Telomere Integrity in Drosophila.Molecular biology and evolution · 2017Article
- The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Genetics · 2016Review
- Evolution and Functional Trajectory of Sir1 in Gene Silencing.Molecular and cellular biology · 2016Article
- The Chromatin and Transcriptional Landscape of Native Saccharomyces cerevisiae Telomeres and Subtelomeric Domains.Genetics · 2015Article
- Trypanosoma brucei TIF2 suppresses VSG switching by maintaining subtelomere integrity.Cell research · 2014Article
- The yeast environmental stress response regulates mutagenesis induced by proteotoxic stress.PLoS genetics · 2013Article
- The enigmatic conservation of a Rap1 binding site in the Saccharomyces cerevisiae HMR-E silencer.G3 (Bethesda, Md.) · 2012Article
- Mutation hot spots in yeast caused by long-range clustering of homopolymeric sequences.Cell reports · 2012Article
- Reinventing heterochromatin in budding yeasts: Sir2 and the origin recognition complex take center stage.Eukaryotic cell · 2011Review
- Evidence for a high mutation rate at rapidly evolving yeast centromeres.BMC evolutionary biology · 2011Article
- Integrated genome-scale prediction of detrimental mutations in transcription networks.PLoS genetics · 2011Article
- Histone H4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in Saccharomyces cerevisiae.PLoS genetics · 2011Article
- Co-evolution of transcriptional silencing proteins and the DNA elements specifying their assembly.PLoS biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Subtelomeric DNA in budding yeasts, like metazoan heterochromatin, is gene poor, repetitive, transiently silenced, and highly dynamic. The rapid evolution of subtelomeric regions is commonly thought to arise from transposon activity and increased recombination between repetitive elements. However, we found evidence of an additional factor in this diversification. We observed a surprising level of nucleotide divergence in transcriptionally silenced regions in inter-species comparisons of Saccharomyces yeasts. Likewise, intra-species analysis of polymorphisms also revealed increased SNP frequencies in both intergenic and synonymous coding positions of silenced DNA. This analysis suggested that silenced DNA in Saccharomyces cerevisiae and closely related species had increased single base-pair substitution that was likely due to the effects of the silencing machinery on DNA replication or repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.