ArticlePLoS genetics2008
A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 60 citations in OpenAlex.
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- Regulation and modulation of biogenic amine neurotransmission inFrontiers in physiology · 2023Review
- Coordinated control of neuronal differentiation and wiring by sustained transcription factors.Science (New York, N.Y.) · 2022Article
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- Tyramine synthesis, vesicular packaging, and the SNARE complex function coordinately in astrocytes to regulate Drosophila alcohol sedation.Addiction biology · 2021Article
- Vesicular neurotransmitter transporters in Drosophila melanogaster.Biochimica et biophysica acta. Biomembranes · 2020Review
- Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization.BMC neuroscience · 2018Article
- Big Lessons from Tiny Flies:International journal of molecular sciences · 2018Review
- Transgenic line for the identification of cholinergic release sites inThe Journal of experimental biology · 2017Article
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- Maintenance of glia in the optic lamina is mediated by EGFR signaling by photoreceptors in adult Drosophila.PLoS genetics · 2015Article
- Perturbations in dopamine synthesis lead to discrete physiological effects and impact oxidative stress response in Drosophila.Journal of insect physiology · 2015Article
- Drosophila melanogaster as a genetic model system to study neurotransmitter transporters.Neurochemistry international · 2014Review
- The redistribution of Drosophila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Long-distance mechanism of neurotransmitter recycling mediated by glial network facilitates visual function in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Unlike other monoamine neurotransmitters, the mechanism by which the brain's histamine content is regulated remains unclear. In mammals, vesicular monoamine transporters (VMATs) are expressed exclusively in neurons and mediate the storage of histamine and other monoamines. We have studied the visual system of Drosophila melanogaster in which histamine is the primary neurotransmitter released from photoreceptor cells. We report here that a novel mRNA splice variant of Drosophila VMAT (DVMAT-B) is expressed not in neurons but rather in a small subset of glia in the lamina of the fly's optic lobe. Histamine contents are reduced by mutation of dVMAT, but can be partially restored by specifically expressing DVMAT-B in glia. Our results suggest a novel role for a monoamine transporter in glia that may be relevant to histamine homeostasis in other systems.
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