ArticleProceedings of the National Academy of Sciences of the United States of America2008
Extensive genomic copy number variation in embryonic stem cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed.
- Copy number normalization distinguishes differential signals driven by copy number differences in ATAC-seq and ChIP-seq.BMC genomics · 2025Article
- Improving laboratory animal genetic reporting: LAG-R guidelines.Nature communications · 2024Review
- Article
- Genetic and Molecular Quality Control of Genetically Engineered Mice.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A method for stabilising the XX karyotype in female mESC cultures.Development (Cambridge, England) · 2022Article
- All models are wrong, but some are useful: Establishing standards for stem cell-based embryo models.Stem cell reports · 2021Review
- When the genome bluffs: a tandem duplication event during generation of a novel Agmo knockout mouse model fools routine genotyping.Cell & bioscience · 2021Article
- Generating mouse models for biomedical research: technological advances.Disease models & mechanisms · 2019Review
- Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential.The EMBO journal · 2016Article
- Achilles' heel of pluripotent stem cells: genetic, genomic and epigenetic variations during prolonged culture.Cellular and molecular life sciences : CMLS · 2016Review
- High-Sensitivity Mass Spectrometry for Probing Gene Translation in Single Embryonic Cells in the Early Frog (Frontiers in cell and developmental biology · 2016Article
- Using the GEMM-ESC strategy to study gene function in mouse models.Nature protocols · 2015Article
- Is mouse embryonic stem cell technology obsolete?Genome biology · 2015Article
- Passage number is a major contributor to genomic structural variations in mouse iPSCs.Stem cells (Dayton, Ohio) · 2014Article
- Landscape of standing variation for tandem duplications in Drosophila yakuba and Drosophila simulans.Molecular biology and evolution · 2014Article
- Article
- Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells.EMBO molecular medicine · 2014Article
- Quality control: Genome maintenance in pluripotent stem cells.The Journal of cell biology · 2014Review
- Cancer quasispecies and stem-like adaptive aneuploidy.F1000Research · 2013Article
- Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Recent analysis of the human and mouse genomes has revealed that highly identical duplicated elements account for >5% of the sequence content. These elements vary in copy number between individuals. Copy number variations (CNVs) contribute significantly to genetic differences among individuals and are increasingly recognized as a causal factor in human diseases with different etiologies. In inbred mouse strains, CNVs have been fixed by inbreeding, but they are highly variable among strains. Within strains, de novo germ-line CNVs can occur, leading to interindividual variation. By analyzing the genome of clonal isolates of mouse ES cells derived from common parental lines, we have uncovered extensive and recurrent CNVs. This variation arises during mitosis and can be cotransmitted into the mouse germ line along with engineered alleles, contributing to genetic variability. The frequency and extent of these genomic changes in ES cells suggests that all somatic tissues in individuals will be mosaics composed of variants of the zygotic genome. Human ES (hES) cells and derived somatic lineages may be similarly affected, challenging the concept of a stable somatic genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.