ArticleEndocrinology2009
Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley.Trends in cell biology · 2025Review
- Diuretics: a review of the pharmacology and effects on glucose homeostasis.Frontiers in pharmacology · 2025Review
- Ion Channels of the Islets in Type 2 Diabetes.Journal of molecular biology · 2020Review
- Insulin Release Mechanism Modulated by Toxins Isolated from Animal Venoms: From Basic Research to Drug Development Prospects.Molecules (Basel, Switzerland) · 2019Review
- Article
- Roles of Voltage-Gated Tetrodotoxin-Sensitive Sodium Channels NaV1.3 and NaV1.7 in Diabetes and Painful Diabetic Neuropathy.International journal of molecular sciences · 2016Review
- Modulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells.Acta physiologica (Oxford, England) · 2015Article
- Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.The Journal of physiology · 2014Article
- SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells.The Journal of physiology · 2014Article
- Multiparameter screening reveals a role for Na+ channels in cytokine-induced β-cell death.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Article
- ATP regulates sodium channel kinetics in pancreatic islet beta cells.The Journal of membrane biology · 2013Article
- Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice.PloS one · 2013Article
- Neurological perspectives on voltage-gated sodium channels.Brain : a journal of neurology · 2012Review
- Toxins that modulate ionic channels as tools for exploring insulin secretion.Cellular and molecular neurobiology · 2010Review
- Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus.The Journal of clinical investigation · 2010Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Glucose-stimulated insulin and glucagon release regulates glucose homeostasis by an excitation-secretion coupling pathway beginning with ATP-sensitive K(+) channel closure, membrane depolarization, and entry of calcium ions to stimulate exocytosis. The contribution of voltage-gated sodium channels to this release pathway is still being elucidated. We demonstrate that loss of Scn1b, a major regulatory subunit expressed with Na(v)1.7 protein in mouse pancreatic islets, reduces glucose-stimulated insulin and glucagon secretion in vitro and in vivo, resulting in severe fed and fasting hypoglycemia. This genetic mouse model is the first to demonstrate that sodium channelopathy impairs the physiological excitation-release coupling pathway for pancreatic insulin and glucagon release.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.