ArticleEuropean radiology2009
Potential surrogate markers of cerebral microvascular angiopathy in asymptomatic subjects at risk of stroke.
Article in European radiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Deep Cascade of Convolutional Neural Networks for Quantification of Enlarged Perivascular Spaces in the Basal Ganglia in Magnetic Resonance Imaging.Diagnostics (Basel, Switzerland) · 2024Article
- In patients who had a stroke or TIA, enlarged perivascular spaces in basal ganglia may cause future haemorrhagic strokes.Stroke and vascular neurology · 2024Article
- Association between homocysteine and white matter hyperintensities in rural-dwelling Chinese people with asymptomatic intracranial arterial stenosis: A population-based study.Brain and behavior · 2021Article
- MRI-visible perivascular spaces as an imaging biomarker in Fabry disease.Journal of neurology · 2021Article
- Re-thinking the Etiological Framework of Neurodegeneration.Frontiers in neuroscience · 2019Review
- Understanding the role of the perivascular space in cerebral small vessel disease.Cardiovascular research · 2018Review
- Perivascular Spaces in Old Age: Assessment, Distribution, and Correlation with White Matter Hyperintensities.AJNR. American journal of neuroradiology · 2018Article
- Structured Learning for 3-D Perivascular Space Segmentation Using Vascular Features.IEEE transactions on bio-medical engineering · 2017Article
- Imaging the Perivascular Space as a Potential Biomarker of Neurovascular and Neurodegenerative Diseases.Cellular and molecular neurobiology · 2016Review
- Primary Open Angle Glaucoma is Associated with MR Biomarkers of Cerebral Small Vessel Disease.Scientific reports · 2016Article
- Dilated perivascular spaces in the Basal Ganglia are a biomarker of small-vessel disease in a very elderly population with dementia.AJNR. American journal of neuroradiology · 2015Article
- Decision support systems for clinical radiological practice -- towards the next generation.The British journal of radiology · 2010Review
- Parkinson disease and comorbid cerebrovascular disease.Nature reviews. Neurology · 2009Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Cerebral microvascular angiopathy (MVA) is associated with clinical vascular risk factors and is characterised by histological changes, including thickening of the walls of arterial vessels and dilatation of the Virchow-Robin spaces (VRS). We have previously described two novel biomarkers of MVA based on magnetic resonance imaging (MRI), VRS dilatation and abnormalities in the transfer of systolic arterial pulsation to the ventricular CSF, which occur as a result of decreased cerebral arterial compliance. These are associated with vascular dementia and treatment-resistant late onset depression. We studied a group of normal subjects at risk of cerebrovascular disease to determine if these biomarkers are present in patients who have no evidence of symptomatic vascular disease. We studied 31 subjects, 16 with three or more vascular risk factors and 15 with one or less significant risk factors. We measured arterial blood flow and CSF flow in the cerebral aqueduct, white matter lesion load, and the distribution and number of VRS. There were significant differences in CSF pulsatility and in VRS in the basal ganglia between the two groups, but no differences in white matter lesion load. We conclude that asymptomatic subjects at risk of stroke have MRI evidence of MVA before white matter lesions become apparent.
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Registered trials
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