ArticleMolecular biology of the cell2009
Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Distinct roles of RECQL5 in RAD51-mediated fork reversal and transcription elongation.Nucleic acids research · 2025Article
- Review
- Genome-wide analysis of KIX gene family for organ size regulation in soybean (Frontiers in plant science · 2023Article
- Expression of DNA Helicase Genes Was Correlated with Homologous Recombination Deficiency in Breast Cancer.Computational and mathematical methods in medicine · 2022Article
- Article
- Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling.ACS chemical biology · 2021Article
- Homologous recombination is reduced in female embryonic stem cells by two active X chromosomes.EMBO reports · 2021Article
- RECQL5 at theFrontiers in cell and developmental biology · 2020Review
- RECQL5 plays an essential role in maintaining genome stability and viability of triple-negative breast cancer cells.Cancer medicine · 2019Article
- The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance.DNA repair · 2019Review
- Molecular-genetic profiling and high-throughputOncotarget · 2017Article
- Review
- Article
- Transcription-replication conflicts: how they occur and how they are resolved.Nature reviews. Molecular cell biology · 2016Review
- Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer.Oncotarget · 2016Article
- Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers.Carcinogenesis · 2016Article
- Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice.World journal of gastroenterology · 2015Article
- RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability.Nature communications · 2015Article
- RECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathway.Nucleic acids research · 2015Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Disruption of replication can lead to loss of genome integrity and increase of cancer susceptibility in mammals. Thus, a replication impediment constitutes a formidable challenge to these organisms. Recent studies indicate that homologous recombination (HR) plays an important role in suppressing genome instability and promoting cell survival after exposure to various replication inhibitors, including a topoisomerase I inhibitor, camptothecin (CPT). Here, we report that the deletion of RecQ helicase Recql5 in mouse ES cells and embryonic fibroblast (MEF) cells resulted in a significant increase in CPT sensitivity and a profound reduction in DNA replication after the treatment with CPT, but not other DNA-damaging agents. This CPT-induced cell death is replication dependent and occurs primarily after the cells had exited the first cell cycle after CPT treatment. Furthermore, we show that Recql5 functions nonredundantly with Rad51, a key factor for HR to protect mouse ES cells from CPT-induced cytotoxicity. These new findings strongly suggest that Recql5 plays an important role in maintaining active DNA replication to prevent the collapse of replication forks and the accumulation of DSBs in order to preserve genome integrity and to prevent cell death after replication stress as a result of topoisomerase I poisoning.
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Registered trials
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