ArticlePlant physiology2009
Flux balance analysis of barley seeds: a computational approach to study systemic properties of central metabolism.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- Enhanced lignin and cellulose metabolism promote cell wall synthesis and growth of wild soybean HRA under alkali stress.Annals of botany · 2025Article
- Transcriptome enhanced rice grain metabolic model identifies histidine level as a marker for grain chalkiness.Scientific reports · 2025Article
- New insights in metabolism modelling to decipher plant-microbe interactions.The New phytologist · 2025Review
- A Guide to Metabolic Network Modeling for Plant Biology.Plants (Basel, Switzerland) · 2025Review
- Biophysical modelling as a tool for advancing plant science and engineering.Frontiers in plant science · 2025Review
- COFrontiers in plant science · 2023Article
- TCA Cycle and Its Relationship with Clavulanic Acid Production: A Further Interpretation by Using a Reduced Genome-Scale Metabolic Model ofBioengineering (Basel, Switzerland) · 2021Article
- Characterization of effects of genetic variants via genome-scale metabolic modelling.Cellular and molecular life sciences : CMLS · 2021Review
- Transcriptome integrated metabolic modeling of carbon assimilation underlying storage root development in cassava.Scientific reports · 2021Article
- SNPeffect: identifying functional roles of SNPs using metabolic networks.The Plant journal : for cell and molecular biology · 2020Article
- Introducing an Optimization- and explicit Runge-Kutta- based Approach to Perform Dynamic Flux Balance Analysis.Scientific reports · 2020Article
- Understanding carbon utilization routes between high and low starch-producing cultivars of cassava through Flux Balance Analysis.Scientific reports · 2019Article
- A genome-scale metabolic model of potato late blight suggests a photosynthesis suppression mechanism.BMC genomics · 2018Article
- The intertwined metabolism during symbiotic nitrogen fixation elucidated by metabolic modelling.Scientific reports · 2018Article
- A Dynamic Multi-Tissue Flux Balance Model Captures Carbon and Nitrogen Metabolism and Optimal Resource Partitioning During Arabidopsis Growth.Frontiers in plant science · 2018Article
- Advances on plant-pathogen interactions from molecular toward systems biology perspectives.The Plant journal : for cell and molecular biology · 2017Review
- Modeling the Metabolism ofFrontiers in genetics · 2017Article
- Article
- In silico metabolic network analysis of Arabidopsis leaves.BMC systems biology · 2016Article
1 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
The accumulation of storage compounds is an important aspect of cereal seed metabolism. Due to the agronomical importance of the storage reserves of starch, protein, and oil, the understanding of storage metabolism is of scientific interest, with practical applications in agronomy and plant breeding. To get insight into storage patterning in developing cereal seed in response to environmental and genetic perturbation, a computational analysis of seed metabolism was performed. A metabolic network of primary metabolism in the developing endosperm of barley (Hordeum vulgare), a model plant for temperate cereals, was constructed that includes 257 biochemical and transport reactions across four different compartments. The model was subjected to flux balance analysis to study grain yield and metabolic flux distributions in response to oxygen depletion and enzyme deletion. In general, the simulation results were found to be in good agreement with the main biochemical properties of barley seed storage metabolism. The predicted growth rate and the active metabolic pathway patterns under anoxic, hypoxic, and aerobic conditions predicted by the model were in accordance with published experimental results. In addition, the model predictions gave insight into the potential role of inorganic pyrophosphate metabolism to maintain seed metabolism under oxygen deprivation.
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