ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Increased cognitive functioning in symptomatic Huntington's disease as revealed by behavioral and event-related potential indices of auditory sensory memory and attention.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature.Brain and behavior · 2026Pooled it
- Dose-Dependent Effects of Catecholaminergic Modulation on Interference Control: Role of Baseline GABA and Glx in Cortico-Subcortical Networks.Human brain mapping · 2025Trial
- Dopamine Modulates the Efficiency of Sensory Evidence Accumulation During Perceptual Decision Making.The international journal of neuropsychopharmacology · 2018Trial
- Characteristics of auditory event-related potential and prediction ofQuantitative imaging in medicine and surgery · 2026Article
- GABA and Glx levels in cortico-subcortical networks predict catecholaminergic effects on response inhibition.Journal of psychopharmacology (Oxford, England) · 2025Article
- Action impulsivity and attention deficits in patients at an early stage of Huntington disease.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Advances in Huntington's Disease Biomarkers: A 10-Year Bibliometric Analysis and a Comprehensive Review.Biology · 2025Review
- The correlation between auditory event-related potentials characteristics and cognitive function in insular glioma patients.Frontiers in neurology · 2025Article
- A Practical Guide for Clinical Approach to Patients With Huntington's Disease in Korea.Journal of movement disorders · 2024Article
- Gamma-Aminobutyric Acid and Glutamate Concentrations in the Striatum and Anterior Cingulate Cortex Not Found to Be Associated with Cognitive Flexibility.Brain sciences · 2023Article
- An Expanded Polyproline Domain Maintains Mutant Huntingtin SolubleFrontiers in molecular neuroscience · 2021Article
- Hearing Loss in Neurological Disorders.Frontiers in cell and developmental biology · 2021Review
- Predictive coding and adaptive behavior in patients with genetically determined cerebellar ataxia--A neurophysiology study.NeuroImage. Clinical · 2019Article
- Problem solving, impulse control and planning in patients with early- and late-stage Huntington's disease.European archives of psychiatry and clinical neuroscience · 2016Article
- Laser Evoked Potentials in Early and Presymptomatic Huntington's Disease.Behavioural neurology · 2016Article
- Hearing and music in dementia.Handbook of clinical neurology · 2015Review
- Cross sectional PET study of cerebral adenosine A₁ receptors in premanifest and manifest Huntington's disease.European journal of nuclear medicine and molecular imaging · 2014Article
- Striatal disorders dissociate mechanisms of enhanced and impaired response selection - Evidence from cognitive neurophysiology and computational modelling.NeuroImage. Clinical · 2014Article
- Transient and steady-state selection in the striatal microcircuit.Frontiers in computational neuroscience · 2013Article
- Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts.Neurotoxicology · 2012Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive functions are thought to deteriorate globally in late stages of various neurodegenerative disorders. Here we describe that this general assumption is not justified and fails in Huntington's disease (HD). Presymptomatic gene mutation carriers (pHDs) and healthy controls performed worse compared with symptomatic HDs in an auditory signal detection task. During task performance, behavioral data and event-related potentials (ERPs) [i.e., MMN (mismatch negativity), P3a, and RON (reorienting negativity)] were recorded. Not only behavioral performance but also neurophysiological correlates of auditory sensory memory and attentional reorientation indicate enhanced performance occurring primal in late stages of a neurodegenerative disorder. Increased activity of the NMDA-receptor system, an assumed pathogenic mechanism in HD, might facilitate signal propagation at striatal level that enables more efficient task execution through a winner-take-all process. The results challenge the view that late stage neurodegeneration is necessarily related to a global decline in cognitive abilities in HD. In contrast, selectively enhanced cognitive functioning can emerge together with otherwise impaired cognitive functioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.