ArticleJournal of virology2009
Analysis of influenza B Virus NS1 protein trafficking reveals a novel interaction with nuclear speckle domains.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- How influenza A virus NS1 impedes transcription of the host cell's messenger RNAs.Npj viruses · 2025Article
- Influenza A virus NS1 suppresses nuclear speckles promoted gene expression by inhibition of transcription.Npj viruses · 2025Article
- Microscopic Analysis of Nuclear Speckles in a Viviparous Reptile.International journal of molecular sciences · 2024Article
- Nyamanini Virus Nucleoprotein and Phosphoprotein Organize Viral Inclusion Bodies That Associate with Host Biomolecular Condensates in the Nucleus.International journal of molecular sciences · 2023Article
- Article
- The Nucleolar Protein LYAR Facilitates Ribonucleoprotein Assembly of Influenza A Virus.Journal of virology · 2018Article
- The Cellular DExD/H-Box RNA Helicase UAP56 Co-localizes With the Influenza A Virus NS1 Protein.Frontiers in microbiology · 2018Article
- Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins.Viruses · 2017Article
- Human interactome of the influenza B virus NS1 protein.The Journal of general virology · 2017Article
- Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins.Nature communications · 2016Article
- Molecular and biochemical characterization of the NS1 protein of non-cultured influenza B virus strains circulating in Singapore.Microbial genomics · 2016Article
- Influenza virus mRNA trafficking through host nuclear speckles.Nature microbiology · 2016Article
- Alterations of Nuclear Architecture and Epigenetic Signatures during African Swine Fever Virus Infection.Viruses · 2015Article
- Genetic characterisation of influenza B viruses detected in Singapore, 2004 to 2009.BMC research notes · 2014Article
- Article
- Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection.The Journal of biological chemistry · 2012Article
- The cellular RNA helicase UAP56 is required for prevention of double-stranded RNA formation during influenza A virus infection.Journal of virology · 2011Article
- Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein.Journal of virology · 2010Article
- Species specificity of the NS1 protein of influenza B virus: NS1 binds only human and non-human primate ubiquitin-like ISG15 proteins.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many proteins that function in the transcription, maturation, and export of metazoan mRNAs are concentrated in nuclear speckle domains, indicating that the compartment is important for gene expression. Here, we show that the NS1 protein of influenza B virus (B/NS1) accumulates in nuclear speckles and causes rounding and morphological changes of the domains, indicating a disturbance in their normal functions. This property was located within the N-terminal 90 amino acids of the B/NS1 protein and was shown to be independent of any other viral gene product. Within this protein domain, we identified a monopartite importin alpha binding nuclear localization signal. Reverse-genetic analysis of this motif indicated that nuclear import and speckle association of the B/NS1 protein are required for the full replication capacity of the virus. In the late phase of virus infection, the B/NS1 protein relocated to the cytoplasm, which occurred in a CRM1-independent manner. The interaction of the B/NS1 protein with nuclear speckles may reflect a recruitment function to promote viral-gene expression. To our knowledge, this is the first functional description of a speckle-associated protein that is encoded by a negative-strand RNA virus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.