ReviewTrends in molecular medicine2008
The complex role of B7 molecules in tumor immunology.
Review in Trends in molecular medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Distinct role of CD86 polymorphisms (rs1129055, rs17281995) in risk of cancer: evidence from a meta-analysis.PloS one · 2014Pooled it
- Unraveling the Clinical Landscape of RNA Modification Regulators with Multi-Omics Insights in Pan-Cancer.Cancers · 2025Article
- Whole-Genome Methylation Sequencing of Large Yellow Croaker (Larimichthys crocea) Liver Under Hypoxia and Acidification Stress.Marine biotechnology (New York, N.Y.) · 2023Article
- Pre-treatment inflamed tumor immune microenvironment is associated with FOLFIRINOX response in pancreatic cancer.Frontiers in oncology · 2023Article
- Immunosuppressive cells in oncolytic virotherapy for glioma: challenges and solutions.Frontiers in cellular and infection microbiology · 2023Review
- Novel insight on predicting prognosis of gastric cancer based on inflammation.Translational cancer research · 2022Article
- New insights into exosome mediated tumor-immune escape: Clinical perspectives and therapeutic strategies.Biochimica et biophysica acta. Reviews on cancer · 2021Review
- Molecular Mechanisms of Drug Resistance in Glioblastoma.International journal of molecular sciences · 2021Review
- Chimeric Antigen Receptor T Cell Therapy: A Novel Modality for Immune Modulation.Chonnam medical journal · 2020Review
- Genetic association between cluster of differentiation 86 variations and sepsis risk: A case-control study.Medicine · 2019Article
- Association of increased B7 protein expression by infiltrating immune cells with progression of gastric carcinogenesis.Medicine · 2019Article
- Editorial: Lymphocyte Functional Crosstalk and Regulation.Frontiers in immunology · 2019Article
- The expressions and significance of B7-H3 and CTLA-4 in the clinical stages of non-small-cell lung cancer.International journal of clinical and experimental pathology · 2019Article
- Expression and clinical significance of programmed death ligand 1 in nasopharyngeal carcinoma.Molecular and clinical oncology · 2018Article
- CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers.International journal of endocrinology · 2018Article
- A polymorphism in the promoter region of PD-L1 serves as a binding-site for SP1 and is associated with PD-L1 overexpression and increased occurrence of gastric cancer.Cancer immunology, immunotherapy : CII · 2017Article
- Preclinical imaging of the co-stimulatory molecules CD80 and CD86 with indium-111-labeled belatacept in atherosclerosis.EJNMMI research · 2016Article
- Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer.Oncoimmunology · 2016Article
- Immune checkpoint blockade therapy for bladder cancer treatment.Investigative and clinical urology · 2016Review
- Ectopic expression of the chemokine CXCL17 in colon cancer cells.British journal of cancer · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
T-cell activation requires the interaction of the T-cell receptor with a cognate major histocompatibility complex (MHC)-peptide complex. Initiated by antigen engagement, the adaptive immune response is orchestrated by a complex balance between stimulatory and inhibitory signals that are predominantly controlled by members of the B7 family. Here, we review the current knowledge on B7 family members concerning their constitutive and regulated expression, modulation of the immune response and their role in the evasion of host immune surveillance. We also discuss recent therapeutic strategies that aim to improve immune-cell recognition of tumors and induce tolerance to autoreactive immune responses in normal tissues by manipulating B7 functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.