Evidence map›Paper›PMID 18986603›Full record

ReviewMicroscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada2008

Cardiovascular imaging using two-photon microscopy.

John A Scherschel, Michael Rubart

Open access · greenAbstract readReview
In one paragraph

Review in Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  9. The continuing evolution of the Langendorff and ejecting murine heart: new advances in cardiac phenotyping.American journal of physiology. Heart and circulatory physiology · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

John A ScherschelDepartment of Pediatrics, Division of Cardiology, Wells Center for Pediatric Research, 1044 West Walnut Street, Indianapolis, IN 46202, USA.
Michael Rubart
Center for Children · USIndiana University – Purdue University Indianapolis · US

Funding

Functional assessment of donor-host cell couplingR01HL075165 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI RUBART-VAN DER LOHE, MICHAEL · 2005 to 2009
$2.1M
NHLBI NIH HHS R01 HL075165
6 · The paper itself

Abstract

Two-photon excitation microscopy has become the standard technique for high resolution deep tissue and intravital imaging. It provides intrinsic three-dimensional resolution in combination with increased penetration depth compared to single-photon confocal microscopy. This article will describe the basic physical principles of two-photon excitation and will review its multiple applications to cardiovascular imaging, including second harmonic generation and fluorescence laser scanning microscopy. In particular, the capability and limitations of multiphoton microscopy to assess functional heterogeneity on a cellular scale deep within intact, Langendorff-perfused hearts are demonstrated. It will also discuss the use of two-photon excitation-induced release of caged compounds for the study of intracellular calcium signaling and intercellular dye transfer.

Indexed as

Microscopy, Fluorescence, MultiphotonAnimalsCardiovascular SystemFluorescent DyesHumansPhotolysisSignal TransductionFluorescent Dyes

Identifiers

PMID18986603
PMCPMC2583458
OpenAlexW2138209081

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.