ArticleThe Journal of experimental medicine1991
Histologic transformation of follicular lymphoma to diffuse lymphoma represents tumor progression by a single malignant B cell.
Article in The Journal of experimental medicine, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 116 citations in OpenAlex.
- Read the clonotype: Next-generation sequencing-based lymphocyte clonality analysis and perspectives for application in pathology.Frontiers in oncology · 2023Article
- Mutational patterns along different evolution paths of follicular lymphoma.Frontiers in oncology · 2022Article
- Natural Barcodes for Longitudinal Single Cell Tracking of Leukemic and Immune Cell Dynamics.Frontiers in immunology · 2021Review
- Composite diffuse large B-cell lymphoma and follicular B-cell lymphoma - case report and review of literature.Maedica · 2014Article
- Diffuse large B-cell lymphoma arising in a composite lymphoma with biclonality by flow cytometry and one monoclonal band by PCR.International journal of clinical and experimental pathology · 2014Article
- Expression of PIK3CA and FOXP1 in gastric and intestinal non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue type.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- Molecular pathways in follicular lymphoma.Leukemia · 2007Review
- Immunohistochemistry in bone marrow pathology: a useful adjunct for morphologic diagnosis.Virchows Archiv : an international journal of pathology · 2005Review
- Relationship between the mutational status of VH genes and pathogenesis of diffuse large B-cell lymphoma in Richter's syndrome.Leukemia · 2004Article
- In situ analysis of the variable heavy chain gene of an IgM/IgG-expressing follicular lymphoma: evidence for interfollicular trafficking of tumor cells.The American journal of pathology · 2002Article
- Analysis of the immunoglobulin heavy chain gene variable region of CD5-positive and -negative diffuse large B cell lymphoma.Leukemia · 2001Article
- Somatic mutation of the 5' noncoding region of the BCL-6 gene is associated with intraclonal diversity and clonal selection in histological transformation of follicular lymphoma.The American journal of pathology · 2000Article
- Composite low grade B-cell lymphomas with two immunophenotypically distinct cell populations are true biclonal lymphomas. A molecular analysis using laser capture microdissection.The American journal of pathology · 1999Article
- Clonal evolution of B cells in transformation from low- to high-grade lymphoma.European journal of immunology · 1999Article
- Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- De novo CD5-positive and Richter's syndrome-associated diffuse large B cell lymphomas are genotypically distinct.The American journal of pathology · 1995Article
- Clonal analysis of three morphologically distinct lymphomas occurring in the same patient.Journal of clinical pathology · 1994Article
- Detection of clonal immunoglobulin gene rearrangements by polymerase chain reaction amplification and single-strand conformational polymorphism analysis.The American journal of pathology · 1993Article
- Genes for interleukin 7 are transcribed in leukemic cell subsets of individuals with chronic lymphocytic leukemia.The Journal of experimental medicine · 1993Article
- Characterization of clonality of Epstein-Barr virus-induced human B lymphoproliferative disease in mice with severe combined immunodeficiency.The American journal of pathology · 1993Article
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3 authors at 1 institution in 1 country.
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Abstract
To investigate the clonal relationship between follicular lymphoma (FL) and transformed diffuse lymphoma (tDL), we examined the expression of tumor idiotype, immunoglobulin (Ig) gene rearrangements and sequence of Ig variable genes in paired tissue specimens. All 16 cases analyzed expressed surface immunoglobulin (sIg) on both the FL and the tDL, though the immunophenotype of one case of FL could not be definitively determined. In 14 of 15 cases, the surface immunophenotype was preserved; the exception was likely secondary to a class switch from IgM to IgG. In 12 of 13 cases, antiidiotypic monoclonal antibodies prepared against the FL reacted with the paired tDL. Analysis of Ig gene rearrangements in four cases by Southern blot hybridization showed evidence of clonal relationships in all cases though concordance was not seen with all probes tested (C kappa, C lambda, JH, PFL1, and PFL2). In the one case that had a discordant L chain rearrangement, sequence analysis of the L chain demonstrated a common mature B cell origin for both the FL and tDL. To determine whether tDL arose from one or more FL cells, the sequences of the H chain variable genes were analyzed. Individual clones of the V region gene of the FL showed a random distribution of changes throughout the sequence. In contrast, individual clones of the V region gene from tDL shared numerous nonrandom sequence alterations, implying a common single cell origin. In conclusion, tDL is a mature B cell and arises by transformation of a single FL cell.
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