ArticleBMC microbiology2008
Chlamydia trachomatis responds to heat shock, penicillin induced persistence, and IFN-gamma persistence by altering levels of the extracytoplasmic stress response protease HtrA.
Article in BMC microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 69 citations in OpenAlex.
- A cohort study of Chlamydia trachomatis treatment failure in women: a study protocol.BMC infectious diseases · 2013Trial
- Iron limitation-induced modulation of transcription in Chlamydia trachomatis.Scientific reports · 2026Article
- Comparative transcriptomics reveals genes commonly induced by distinct stressors inInfection and immunity · 2026Article
- Comparative Transcriptomics Reveals Genes Commonly Induced by Distinct Stressors inbioRxiv : the preprint server for biology · 2025Article
- Secreted ISG15 induced by Chlamydia trachomatis infection exerts immunomodulatory effects on IFN-γ defense and inflammation.PLoS pathogens · 2025Article
- A lineage-specific heat-induced feedback loop controls HrcA to promote chlamydial fitness under stress.bioRxiv : the preprint server for biology · 2025Article
- Intranasal delivery ofHuman vaccines & immunotherapeutics · 2024Article
- HtrA, fatty acids, and membrane protein interplay inJournal of bacteriology · 2024Article
- 4-Chloroisocoumarins as Chlamydial Protease Inhibitors and Anti-Chlamydial Agents.Molecules (Basel, Switzerland) · 2024Article
- Identification and Characterization of an HtrA Sheddase Produced byInternational journal of molecular sciences · 2023Article
- The Periplasmic Tail-Specific Protease, Tsp, Is Essential for Secondary Differentiation inJournal of bacteriology · 2023Article
- Article
- Molecular pathogenesis ofFrontiers in cellular and infection microbiology · 2023Review
- Persistence of obligate intracellular pathogens: alternative strategies to overcome host-specific stresses.Frontiers in cellular and infection microbiology · 2023Review
- Repeat infections with chlamydia in women may be more transcriptionally active with lower responses from some immune genes.Frontiers in public health · 2022Article
- Chlamydial clinical isolates show subtle differences in persistence phenotypes and growthAccess microbiology · 2021Article
- Koala cathelicidin PhciCath5 has antimicrobial activity, including against Chlamydia pecorum.PloS one · 2021Article
- Robust Heat Shock Response inFrontiers in microbiology · 2021Article
- Structure and Metal Binding Properties ofJournal of bacteriology · 2019Article
- High expression of IDO1 and TGF-β1 during recurrence and post infection clearance with Chlamydia trachomatis, are independent of host IFN-γ response.BMC infectious diseases · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChlamydia trachomatis, an obligate intracellular human pathogen, is the most prevalent bacterial sexually transmitted infection worldwide and a leading cause of preventable blindness. HtrA is a virulence and stress response periplasmic serine protease and molecular chaperone found in many bacteria. Recombinant purified C. trachomatis HtrA has been previously shown to have both activities. This investigation examined the physiological role of Chlamydia trachomatis HtrA.
resultsThe Chlamydia trachomatis htrA gene complemented the lethal high temperature phenotype of Escherichia coli htrA- (>42 degrees C). HtrA levels were detected to increase by western blot and immunofluorescence during Chlamydia heat shock experiments. Confocal laser scanning microscopy revealed a likely periplasmic localisation of HtrA. During penicillin induced persistence of Chlamydia trachomatis, HtrA levels (as a ratio of LPS) were initially less than control acute cultures (20 h post infection) but increased to more than acute cultures at 44 h post infection. This was unlike IFN-gamma persistence where lower levels of HtrA were observed, suggesting Chlamydia trachomatis IFN-gamma persistence does not involve a broad stress response.
conclusionThe heterologous heat shock protection for Escherichia coli, and increased HtrA during cell wall disruption via penicillin and heat shock, indicates an important role for HtrA during high protein stress conditions for Chlamydia trachomatis.
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