ArticleJournal of neuroinflammation2008
Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice.
Article in Journal of neuroinflammation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- The Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory Disorders-A Systematic Review.Frontiers in immunology · 2018Pooled it
- Role of Kinin BCellular and molecular neurobiology · 2026Article
- The immunomodulatory potential of bradykinin signaling in autoimmune conditions.Frontiers in immunology · 2026Review
- Article
- Multiple Sclerosis: Inflammatory and Neuroglial Aspects.Current issues in molecular biology · 2023Review
- RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells.Molecular medicine reports · 2022Article
- BBritish journal of pharmacology · 2020Article
- IL-1β Is Involved with the Generation of Pain in Experimental Autoimmune Encephalomyelitis.Molecular neurobiology · 2016Article
- Automatic detection of motion blur in intravital video microscopy image sequences via directional statistics of log-Gabor energy maps.Medical & biological engineering & computing · 2015Article
- Differential gene expression of bradykinin receptors 1 and 2 in peripheral monocytes from patients with essential hypertension.Journal of human hypertension · 2014Article
- Balance between the two kinin receptors in the progression of experimental focal and segmental glomerulosclerosis in mice.Disease models & mechanisms · 2014Article
- Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses.Acta neuropathologica · 2014Article
- Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptors.Cellular signalling · 2012Article
- G protein-coupled receptors as therapeutic targets for multiple sclerosis.Cell research · 2012Review
- Mechanisms of dendritic cell trafficking across the blood-brain barrier.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Review
- Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Article
- Kinin B1 receptors contributes to acute pain following minor surgery in humans.Molecular pain · 2010Article
- Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.Nature medicine · 2009Article
- Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms.Progress in neurobiologyReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKinins are important mediators of inflammation and act through stimulation of two receptor subtypes, B1 and B2. Leukocyte infiltration contributes to the pathogenesis of autoimmune inflammation in the central nervous system (CNS), occurring not only in multiple sclerosis (MS) but also in experimental autoimmune encephalomyelitis (EAE). We have previously shown that the chemokines CCL2 and CCL5 play an important role in the adhesion of leukocytes to the brain microcirculation in EAE. The aim of the present study was to evaluate the relevance of B2 receptors to leukocyte-endothelium interactions in the cerebral microcirculation, and its participation in CNS inflammation in the experimental model of myelin-oligodendrocyte-glycoprotein (MOG)(35-55)-induced EAE in mice.
methodsIn order to evaluate the role of B2 receptor in the cerebral microvasculature we used wild-type (WT) and kinin B2 receptor knockout (B2-/-) mice subjected to MOG(35-55)-induced EAE. Intravital microscopy was used to investigate leukocyte recruitment on pial matter vessels in B2-/- and WT EAE mice. Histological documentation of inflammatory infiltrates in brain and spinal cords was correlated with intravital findings. The expression of CCL5 and CCL2 in cerebral tissue was assessed by ELISA.
resultsClinical parameters of disease were reduced in B2-/- mice in comparison to wild type EAE mice. At day 14 after EAE induction, there was a significant decrease in the number of adherent leukocytes, a reduction of cerebral CCL5 and CCL2 expressions, and smaller inflammatory and degenerative changes in B2-/- mice when compared to WT.
conclusionOur results suggest that B2 receptors have two major effects in the control of EAE severity: (i) B2 regulates the expression of chemokines, including CCL2 and CCL5, and (ii) B2 modulates leukocyte recruitment and inflammatory lesions in the CNS.
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