ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2008
Effect of bone morphogenetic protein signaling on development of the jaw skeleton.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Medication-related osteonecrosis of the jaw (MRONJ): a review of pathogenesis hypothesis and therapy strategies.Archives of toxicology · 2024Review
- Two Proximally Close Priority Candidate Genes for diplopodia-1, an Autosomal Inherited Craniofacial-Limb Syndrome in the Chicken: MRE11 and GPR83.The Journal of heredity · 2019Article
- The Forgotten Skeletogenic Condensations: A Comparison of Early Skeletal Development Amongst Vertebrates.Journal of developmental biology · 2019Review
- Neural crest and the origin of species-specific pattern.Genesis (New York, N.Y. : 2000) · 2018Review
- Article
- Multigenic Delineation of Lower Jaw Deformity in Triploid Atlantic Salmon (Salmo salar L.).PloS one · 2016Article
- Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton.Developmental biology · 2014Article
- Advanced BMP gene therapies for temporal and spatial control of bone regeneration.Journal of dental research · 2013Review
- New perspectives on pharyngeal dorsoventral patterning in development and evolution of the vertebrate jaw.Developmental biology · 2012Review
- The face signature of fibrodysplasia ossificans progressiva.American journal of medical genetics. Part A · 2012Article
- Neural crest cells pattern the surface cephalic ectoderm during FEZ formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Signaling by SHH rescues facial defects following blockade in the brain.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Mechanisms that underlie co-variation of the brain and face.Genesis (New York, N.Y. : 2000) · 2011Review
- Article
- Analysis of chick (Gallus gallus) middle ear columella formation.BMC developmental biology · 2010Article
- The ciliary protein C2cd3 is required for mandibular musculoskeletal tissue patterning.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Bone morphogenetic proteins (BMPs) regulate many aspects of development including skeletogenesis. Here, we examined the response of neural crest-derived cells to ectopic BMP signaling by infecting avian embryos with retroviruses encoding Bmp-2 or Bmp-4 at various times of development. Infection at stages 10 and 15 transformed large areas of the skull into cartilage by day 13. At this time cartilage condensations were still forming, which revealed the presence of uncommitted mesenchymal cells. By day 19, hypertrophic chondrocytes were present in the cartilage possibly due to changes in the perichondrium that relieved repression on hypertrophy. While these cells expressed Sox9, Collagen-2, Runx2, Ihh, Noggin, and Collagen-10, cartilage was not replaced by bone. Whether this is an intrinsic property of the skull cartilage, or results from sustained Bmp signaling is not known.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.