ArticleCerebellum (London, England)2008
The role of SK calcium-dependent potassium currents in regulating the activity of deep cerebellar nucleus neurons: a dynamic clamp study.
Article in Cerebellum (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Synchronicity and Rhythmicity of Purkinje Cell Firing during Generalized Spike-and-Wave Discharges in a Natural Mouse Model of Absence Epilepsy.Frontiers in cellular neuroscience · 2017Article
- Emerging therapies in Friedreich's ataxia.Neurodegenerative disease management · 2016Review
- Gain control of synaptic response function in cerebellar nuclear neurons by a calcium-activated potassium conductance.Cerebellum (London, England) · 2013Article
- Implementing dynamic clamp with synaptic and artificial conductances in mouse retinal ganglion cells.Journal of visualized experiments : JoVE · 2013Article
- The cellular building blocks of breathing.Comprehensive Physiology · 2012Review
- Spatiotemporal firing patterns in the cerebellum.Nature reviews. Neuroscience · 2011Review
- Using computer simulations to determine the limitations of dynamic clamp stimuli applied at the soma in mimicking distributed conductance sources.Journal of neurophysiology · 2011Article
- Rebound discharge in deep cerebellar nuclear neurons in vitro.Cerebellum (London, England) · 2010Review
- Dynamic clamp: alteration of response properties and creation of virtual realities in neurophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used the method of dynamic current clamping to determine the properties and function of the SK calcium-dependent K(+) current in neurons of the deep cerebellar nuclei (DCN). As previously reported, block of SK current with apamin leads to bursting of DCN neurons and a steepening of the f-I curve. We show here that the properties of the slow spike afterhyperpolarization are fully controlled by SK current and we derive kinetic properties of this current that explain its action on DCN neurons. Overall, the SK current provides an effective mechanism to tune the regularity of spiking and the f-I curve of DCN neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.