ArticleEuropean journal of nuclear medicine and molecular imaging2009
Detection of gastric cancer using 18F-FLT PET: comparison with 18F-FDG PET.
Article in European journal of nuclear medicine and molecular imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Evaluation of FAPI PET imaging in gastric cancer: a systematic review and meta-analysis.Theranostics · 2023Pooled it
- Pooled it
- Comparison ofTomography (Ann Arbor, Mich.) · 2022Article
- Imaging of Gastric Carcinomatosis.Journal of clinical medicine · 2021Article
- Dual time point [18F]Flurodeoxyglucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) with water gastric distension in differentiation between malignant and benign gastric lesions.European journal of radiology open · 2020Article
- Imaging peritoneal metastasis of gastric cancer withThe British journal of radiology · 2018Article
- Preoperative staging of nodal status in gastric cancer.Translational gastroenterology and hepatology · 2017Review
- Evaluation ofEJNMMI research · 2016Article
- ¹⁸F-FLT PET/CT as an imaging tool for early prediction of pathological response in patients with locally advanced breast cancer treated with neoadjuvant chemotherapy: a pilot study.European journal of nuclear medicine and molecular imaging · 2015Article
- Correlations of (18)F-fluorothymidine uptake with pathological tumour size, Ki-67 and thymidine kinase 1 expressions in primary and metastatic lymph node colorectal cancer foci.European radiology · 2014Article
- Assessment of (18)F-fluorodeoxyglucose positron emission tomography combined with computed tomography in the preoperative management of patients with gastric cancer.International journal of clinical oncology · 2014Article
- Repopulation of tumor cells during fractionated radiotherapy and detection methods (Review).Oncology letters · 2014Article
- Diagnosis and evaluation of gastric cancer by positron emission tomography.World journal of gastroenterology · 2014Review
- Imaging of Gastric Cancer Metabolism Using 18 F-FDG PET/CT.Journal of gastric cancer · 2014Review
- Preclinical evaluation of a novel c-Met inhibitor in a gastric cancer xenograft model using small animal PET.Molecular imaging and biology · 2013Article
- Assessment of cellular proliferation in tumors by PET using 18F-ISO-1.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Article
- Evaluation of FLT-PET/CT usefulness in diagnosis and qualification for surgical treatment of gastric cancer.Contemporary oncology (Poznan, Poland) · 2013Article
- (18)F-FLT PET/CT in Patients with Gastric Carcinoma.Gastroenterology research and practice · 2013Article
- Role of ¹⁸F 2-fluoro-2-deoxyglucose positron emission tomography in upper gastrointestinal malignancies.World journal of gastroenterology · 2011Review
- Gastric cancer: surgery in 2011.Langenbeck's archives of surgery · 2011Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe prospectively investigated the feasibility of 3'-deoxy-3'-(18)F-fluorothymidine (FLT) positron emission tomography (PET) for the detection of gastric cancer, in comparison with 2-deoxy-2-(18)F-fluoro-D-glucose (FDG) PET, and determined the degree of correlation between the two radiotracers and proliferative activity as indicated by Ki-67 index.
methodsA total of 21 patients with newly diagnosed advanced gastric cancer were examined with FLT PET and FDG PET. Tumour lesions were identified as areas of focally increased uptake, exceeding that of surrounding normal tissue. For semiquantitative analysis, the maximal standardized uptake value (SUV) was calculated.
resultsFor detection of advanced gastric cancer, the sensitivities of FLT PET and FDG PET were 95.2% and 95.0%, respectively. The mean (+/-SD) SUV for FLT (7.0 +/- 3.3) was significantly lower than that for FDG (9.4 +/- 6.3 p < 0.05). The mean FLT SUV and FDG SUV in nonintestinal tumours were higher than in intestinal tumours, although the difference was not statistically significant. The mean (+/-SD) FLT SUV in poorly differentiated tumours (8.5 +/- 3.5) was significantly higher than that in well and moderately differentiated tumours (5.3 +/- 2.1; p < 0.04). The mean FDG SUV in poorly differentiated tumours was higher than in well and moderately differentiated tumours, although the difference was not statistically significant. There was no significant correlation between Ki-67 index and either FLT SUV or FDG SUV.
conclusionFLT PET showed as high a sensitivity as FDG PET for the detection of gastric cancer, although uptake of FLT in gastric cancer was significantly lower than that of FDG.
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