ArticleBritish journal of cancer2008
Two-marker protein profile predicts poor prognosis in patients with early rectal cancer.
Article in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Tumour immune microenvironment prognostic factors in locally advanced rectal cancer, a systematic review.Frontiers in oncology · 2025Pooled it
- Increased expression of Ki-67 is a poor prognostic marker for colorectal cancer patients: a meta analysis.BMC cancer · 2019Pooled it
- The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis.British journal of cancer · 2011Pooled it
- Systematic Analysis of the Clinical Significance of Hyaluronan-Mediated Motility Receptor in Colorectal Cancer.Frontiers in molecular biosciences · 2021Article
- Prognostic significance of CD168 overexpression in colorectal cancer.Oncology letters · 2016Article
- Receptor for Hyaluronic Acid-Mediated Motility is Associated with Poor Survival in Pancreatic Ductal Adenocarcinoma.Journal of Cancer · 2015Article
- Combined preoperative CEA and CD44v6 improves prognostic value in patients with stage I and stage II colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014Article
- RKIP-mediated chemo-immunosensitization of resistant cancer cells via disruption of the NF-κB/Snail/YY1/RKIP resistance-driver loop.Critical reviews in oncogenesis · 2014Review
- High frequency of CD8 positive lymphocyte infiltration correlates with lack of lymph node involvement in early rectal cancer.Disease markers · 2014Article
- RAF-kinase inhibitor protein (RKIP) downregulation in esophageal cancer and its metastases.Clinical & experimental metastasis · 2012Article
- Inhibition of hyaluronan synthase-3 decreases subcutaneous colon cancer growth by increasing apoptosis.Anti-cancer agents in medicinal chemistry · 2011Article
- Cancer immunology--analysis of host and tumor factors for personalized medicine.Nature reviews. Clinical oncology · 2011Review
- Prognostic value of colorectal cancer biomarkers.Cancers · 2011Article
- Prognostic impact of CD168 expression in gastric cancer.BMC cancer · 2011Article
- T cells and adoptive immunotherapy: recent developments and future prospects in gastrointestinal oncology.Clinical & developmental immunology · 2011Review
- Raf kinase inhibitor protein suppresses nuclear factor-κB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression.Cancer letters · 2010Article
- Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review.The Journal of pathology · 2010Review
- Prognostic significance of receptor for hyaluronan acid-mediated motility (CD168) in acute pediatric leukemias - assessment of clinical outcome, post induction, end of treatment and minimal residual disease.Hematology, transfusion and cell therapyArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to establish an immunohistochemical protein profile to complement preoperative staging and identify rectal cancer patients at high-risk of adverse outcome. Immunohistochemistry was performed on a tissue microarray including 482 rectal cancers for APAF-1, EphB2, MST1, Ki67, p53, RHAMM, RKIP and CD8(+) tumour infiltrating lymphocytes (TILs). After resampling of the data and multivariable analysis, the most reproducible markers were combined and prognosis evaluated as stratified by pT and pN status. In multivariable analysis, only positive RHAMM (P<0.001; HR=1.94 (1.44-2.61)) and loss of CD8(+) TILs (P=0.006; HR=0.63 (0.45-0.88)) were independent prognostic factors. The 5-year cancer-specific survival rate for RHAMM+/TIL- patients was 30% (95% CI 21-40%) compared to 76% (95% CI: 66-84%) for RHAMM-/TIL+ patients (P<0.001). The 5-year cancer-specific survival of T1/T2/RHAMM+/TIL- patients was 48% (20-72%) and significantly worse compared to T3/T4/RHAMM-/TIL+ patients (71% 95% CI 56-82%); P=0.039). Stratifying by nodal status, only N+/RHAMM+/TIL- patients demonstrated a significantly worse prognosis than N0/RHAMM+/TIL- patients (P=0.005). Loss of CD8(+) TILs was predictive of local recurrence in RHAMM+ tumours (P=0.009) only. RHAMM and CD8(+) TILs may assist in identifying early stage rectal cancer patients facing a particularly poor prognosis and who may derive a benefit from preoperative therapy.
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