ArticleMolecular systems biology2008
Finding multiple target optimal intervention in disease-related molecular network.
Article in Molecular systems biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed.
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- Computational systems biology in disease modeling and control, review and perspectives.NPJ systems biology and applications · 2022Review
- Utility of constraints reflecting system stability on analyses for biological models.PLoS computational biology · 2022Article
- Machine learning methods, databases and tools for drug combination prediction.Briefings in bioinformatics · 2022Article
- PINet 1.0: A pathway network-based evaluation of drug combinations for the management of specific diseases.Frontiers in molecular biosciences · 2022Article
- A Candidate Drug Screen Strategy: The Discovery of Oroxylin A in Scutellariae Radix Against SepsisFrontiers in pharmacology · 2022Article
- Computational Methods for Structure-Based Drug Design Through System Biology.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Network medicine in Cardiovascular Research.Cardiovascular research · 2021Review
- Application of network link prediction in drug discovery.BMC bioinformatics · 2021Article
- Disentangling the Molecular Pathways of Parkinson's Disease using Multiscale Network Modeling.Trends in neurosciences · 2021Review
- Synergistic Effect of Barbadensis miller and Marsdenia Condurango Extracts Induces Apoptosis Promotes Oxidative Stress by Limiting Proliferation of Cervical Cancer and Liver Cancer Cells.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- GardeninA confers neuroprotection against environmental toxin in a Drosophila model of Parkinson's disease.Communications biology · 2021Article
- An efficient computational method for predicting drug-target interactions using weighted extreme learning machine and speed up robot features.BioData mining · 2021Article
- Machine learning approaches and databases for prediction of drug-target interaction: a survey paper.Briefings in bioinformatics · 2021Review
- DaiCee: A database for anti-cancer compounds with targets and side effect profiles.Bioinformation · 2020Article
- A Multi-Label Learning Framework for Drug Repurposing.Pharmaceutics · 2019Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drugs against multiple targets may overcome the many limitations of single targets and achieve a more effective and safer control of the disease. Numerous high-throughput experiments have been performed in this emerging field. However, systematic identification of multiple drug targets and their best intervention requires knowledge of the underlying disease network and calls for innovative computational methods that exploit the network structure and dynamics. Here, we develop a robust computational algorithm for finding multiple target optimal intervention (MTOI) solutions in a disease network. MTOI identifies potential drug targets and suggests optimal combinations of the target intervention that best restore the network to a normal state, which can be customer designed. We applied MTOI to an inflammation-related network. The well-known side effects of the traditional non-steriodal anti-inflammatory drugs and the recently recalled Vioxx were correctly accounted for in our network model. A number of promising MTOI solutions were found to be both effective and safer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.