ArticleExperimental & molecular medicine2008
Heritability and linkage study on heart rates in a Mongolian population.
Article in Experimental & molecular medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Genome-wide linkage analysis for ocular and nasal anthropometric traits in a Mongolian population.Experimental & molecular medicine · 2010Article
- Analysis of genetic and non-genetic factors that affect the QTc interval in a Mongolian population: the GENDISCAN study.Experimental & molecular medicine · 2009Article
- Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria.Experimental & molecular medicine · 2009Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Elevated heart rate has been proposed as an independent risk factor for cardiovascular diseases, but their interrelationships are not well understood. In this study, we performed a genome-wide linkage scan in 1,026 individuals (mean age 30.6 years, 54.5% women) from 73 extended families of Mongolia and determined quantitative trait loci that influence heart rate. The DNA samples were genotyped using deCODE 1,039 microsatellite markers for 3 cM density genome-wide linkage scan. Correlation analysis was carried out to evaluate the correlation of the covariates and the heart rate. T-tests of the heart rate were also performed on sex, smoking and alcohol intake. Consequently, this model was used in a nonparametric genome-wide linkage analysis using variance component model to create a multipoint logarithm of odds (LOD) score and a corresponding P value. In the adjusted model, the heritability of heart rate was estimated as 0.32 (P<.0001) and a maximum multipoint LOD score of 2.03 was observed in 77 cM region at chromosome 18. The second largest LOD score of 1.52 was seen on chromosome 5 at 216 cM. Genes located on the specified locations in chromosomes 5 and 18 may be involved in the regulation of heart rate.
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