Evidence map›Paper›PMID 18984957›Full record

ArticleDementia and geriatric cognitive disorders2008

Neural correlates of caregiver burden in cortical basal syndrome and frontotemporal dementia.

K M Knutson, G Zamboni, M C Tierney, J Grafman

Open access · bronzeAbstract read
In one paragraph

Article in Dementia and geriatric cognitive disorders, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. The contribution of behavioral features to caregiver burden in FTLD spectrum disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  2. Caregiver strain in progressive supranuclear palsy and corticobasal syndromes.Journal of neural transmission (Vienna, Austria : 1996) · 2021
    Article
  3. Article
  4. Article
  5. Article
  6. Caregiver burden in frontotemporal degeneration and corticobasal syndrome.Dementia and geriatric cognitive disorders · 2013
    Article
  7. Article
  8. Article
  9. PET scan perfusion imaging in the Prader-Willi syndrome: new insights into the psychiatric and social disturbances.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

K M KnutsonCognitive Neuroscience Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1440, USA.
G Zamboni
M C Tierney
J Grafman
National Institute of Neurological Disorders and Stroke · USNational Institutes of Health · US

Funding

Frontotemporal DementiasZ01NS003023 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI GRAFMAN, JORDAN · 2007 to 2008
$1.8M
Frontotemporal DementiasZIANS003023 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI KORETSKY, ALAN · 2009 to 2011
$1.3M
Intramural NIH HHS Z01 NS003023Intramural NIH HHS Z99 NS999999
6 · The paper itself

Abstract

aimsTo determine areas of atrophy in patients that are associated with caregiver burden.

methodsWe measured caregiver burden, dementia and neuropsychiatric scores in 22 patients with corticobasal syndrome (CBS) and 25 with frontotemporal dementia (FTD), and in 14 healthy controls. We used voxel-based morphometry to correlate caregiver burden with gray matter loss.

resultsIncreased dementia and behavioral disturbances contributed to higher burden scores in CBS patients, while behavioral disturbances alone significantly affected burden scores in frontal-variant FTD (FTD-fv) patients. In CBS patients, caregiver burden scores correlated with atrophy in left inferior and middle temporal gyri.

conclusionsCaregivers of FTD-fv patients had significantly higher burden scores than caregivers of CBS patients. Damage to areas important in semantic knowledge appears critical in increased burden for CBS caregivers.

Indexed as

AgedBasal Ganglia DiseasesBehaviorCaregiversCost of IllnessDementiaFemaleHumansKnowledgeMagnetic Resonance ImagingMaleMiddle AgedPsychiatric Status Rating ScalesStress, Psychological

Identifiers

PMID18984957
PMCPMC2596937
OpenAlexW2024423048

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.