ArticleAmerican journal of physiology. Endocrinology and metabolism2009
Proteomic changes associated with diabetes in the BB-DP rat.
Article in American journal of physiology. Endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Metabolic effects of mulberry branch bark powder on diabetic mice based on GC-MS metabolomics approach.Nutrition & metabolism · 2019Article
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- Altered Skeletal Muscle Mitochondrial Proteome As the Basis of Disruption of Mitochondrial Function in Diabetic Mice.Diabetes · 2016Article
- Hepatic proteomic analysis revealed altered metabolic pathways in insulin resistant Akt1(+/-)/Akt2(-/-) mice.Metabolism: clinical and experimental · 2015Article
- Proteomic analysis of gastrocnemius muscle in rats with streptozotocin-induced diabetes and chronically exposed to fluoride.PloS one · 2014Article
- Article
- Glucocorticoid receptor is involved in the breed-dependent transcriptional regulation of mtDNA- and nuclear-encoded mitochondria genes in the liver of newborn piglets.BMC veterinary research · 2013Article
- Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.Circulation research · 2013Article
- Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions.PloS one · 2013Article
- Proteomic analysis of protease resistant proteins in the diabetic rat kidney.Molecular & cellular proteomics : MCP · 2013Article
- Review
- Regulation of oxidative phosphorylation complex activity: effects of tissue-specific metabolic stress within an allometric series and acute changes in workload.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Pathobiochemical changes in diabetic skeletal muscle as revealed by mass-spectrometry-based proteomics.Journal of nutrition and metabolism · 2012Article
- Proteomic analysis of glycated proteins from streptozotocin-induced diabetic rat kidney.Molecular biotechnology · 2012Article
- Homogenous protein programming in the mammalian left and right ventricle free walls.Physiological genomics · 2011Article
- Mitochondrial dysfunction in diabetic cardiomyopathy.Biochimica et biophysica acta · 2011Review
- Protein composition and function of red and white skeletal muscle mitochondria.American journal of physiology. Cell physiology · 2011Article
- What can we learn about cardioprotection from the cardiac mitochondrial proteome?Cardiovascular research · 2010Review
- The mitochondrial proteome: a dynamic functional program in tissues and disease states.Environmental and molecular mutagenesis · 2010Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
These studies were structured with the aim of utilizing emerging technologies in two-dimensional (2D) gel electrophoresis and mass spectrometry to evaluate protein expression changes associated with type 1 diabetes. We reasoned that a broad examination of diabetic tissues at the protein level might open up novel avenues of investigation of the metabolic and signaling pathways that are adversely affected in type 1 diabetes. This study compared the protein expression of the liver, heart, and skeletal muscle of diabetes-prone rats and matched control rats by semiquantitative liquid chromatography-mass spectrometry and differential in-gel 2D gel electrophoresis. Differential expression of 341 proteins in liver, 43 in heart, and 9 (2D gel only) in skeletal muscle was detected. These data were assembled into the relevant metabolic pathways affected primarily in liver. Multiple covalent modifications were also apparent in 2D gel analysis. Several new hypotheses were generated by these data, including mechanisms of net cytosolic protein oxidation, formaldehyde generation by the methionine cycle, and inhibition of carbon substrate oxidation via reduction in citrate synthase and short-chain acyl-CoA dehydrogenase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.