ArticleThe Plant cell2008
The Arabidopsis GRAS protein SCL14 interacts with class II TGA transcription factors and is essential for the activation of stress-inducible promoters.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers.
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148 citing papers in PubMed, 296 citations in OpenAlex.
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- Genome-Wide Identification of the GRAS Transcription Factor Family inInternational journal of molecular sciences · 2026Article
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- Genome-wide identification and expression analysis of the PnNPR-PnTGA gene family reveal its potential role in response to biotic stresses in Panax notoginseng.BMC plant biology · 2026Article
- miR398-SlCSD1 module participates in the SA-HJournal of advanced research · 2026Article
- Identification and expression profiling of the GRAS gene family reveals candidate genes for enhancing abiotic stress tolerance in lentil.BMC plant biology · 2026Article
- Molecular resilience: genetic analysis of multiple-stress tolerance (osmotic, salinity, cold and heat) during potato (Frontiers in plant science · 2026Article
- β-cyclocitral as an apocarotenoid stress signal: biosynthesis, hormonal crosstalk, and emerging omics perspectives in plant abiotic stress tolerance.Frontiers in plant science · 2026Review
- A mutation of GRAS SCL14 gene confers moderate sensitivity to the herbicide bentazon in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Functional characterization of AsGRAS24 in Avena sativa reveals its role in enhancing salt tolerance via antioxidant and hormonal regulation in transgenic Arabidopsis thaliana.BMC plant biology · 2025Article
- Decoding the GRAS code: evolutionary phylogeny and functional diversification of a key gene family in Populus simonii.BMC plant biology · 2025Article
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- AcNAC10, regulated by AcTGA07, enhances kiwifruit resistance to Pseudomonas syringae pv. actinidiae via inhibiting jasmonic acid pathway.Molecular horticulture · 2025Article
- GWAS and transcriptome analyses unravel ZmGRAS15 regulates drought tolerance and root elongation in maize.BMC genomics · 2025Article
- Redox-inactive CC-type glutaredoxins interfere with TGA transcription factor-dependent repression of target promoters in roots.The Plant cell · 2025Article
- Genome-Wide Identification, Expression, and Protein Interaction ofInternational journal of molecular sciences · 2025Article
- Identification of two new GRAS transcription factors and expression analysis of these genes inFrontiers in plant science · 2025Article
- β-cyclocitral as a cross-species mediator of abiotic stress signaling: insights and future directions toward crop improvement.Frontiers in plant science · 2025Review
- A CW-type zinc finger protein is involved in RES-oxylipin signaling and the response to abiotic stress inFrontiers in plant science · 2025Article
88 more citing papers are in PubMed but not listed here.
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The plant signaling molecule salicylic acid (SA) and/or xenobiotic chemicals like the auxin mimic 2,4-D induce transcriptional activation of defense- and stress-related genes that contain activation sequence-1 (as-1)-like cis-elements in their promoters. as-1-like sequences are recognized by basic/leucine zipper transcription factors of the TGA family. Expression of genes related to the SA-dependent defense program systemic acquired resistance requires the TGA-interacting protein NPR1. However, a number of as-1-containing promoters can be activated independently from NPR1. Here, we report the identification of Arabidopsis thaliana SCARECROW-like 14 (SCL14), a member of the GRAS family of regulatory proteins, as a TGA-interacting protein that is required for the activation of TGA-dependent but NPR1-independent SA- and 2,4-D-inducible promoters. Chromatin immunoprecipitation experiments revealed that class II TGA factors TGA2, TGA5, and/or TGA6 are needed to recruit SCL14 to promoters of selected SCL14 target genes identified by whole-genome transcript profiling experiments. The coding regions and the expression profiles of the SCL14-dependent genes imply that they might be involved in the detoxification of xenobiotics and possibly endogenous harmful metabolites. Consistently, plants ectopically expressing SCL14 showed increased tolerance to toxic doses of the chemicals isonicotinic acid and 2,4,6-triiodobenzoic acid, whereas the scl14 and the tga2 tga5 tga6 mutants were more susceptible. Hence, the TGA/SCL14 complex seems to be involved in the activation of a general broad-spectrum detoxification network upon challenge of plants with xenobiotics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.