Evidence map›Paper›PMID 18984575›Full record

ArticleGenetics2009

Population genetic inference from resequencing data.

Rong Jiang, Simon Tavaré, Paul Marjoram

Erratum issuedAbstract read
In one paragraph

Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Population genetic studies in the genomic sequencing era.Dong wu xue yan jiu = Zoological research · 2015
    Review
  5. Parameter-free methods distinguish Wnt pathway models and guide design of experiments.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

3 authors.

Rong JiangDepartment of Oncology, University of Cambridge, Cambridge CB2 0RE, UK.
Simon Tavaré
Paul Marjoram

Funding

Implications of haplotype structure in the human genomeP50HG002790 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TAVARE, SIMON · 2003 to 2013
$29.9M
Computational Methods for Fine MappingR01GM069890 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MARJORAM, PAUL · 2004 to 2007
$1.9M
Computational Methods for Functional GenomicsR01GM067243 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TAVARE, SIMON · 2002 to 2005
$1.6M
Statistical Methods for Relating Sequence Data to PhenotypeR01MH084678 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MARJORAM, PAUL · 2008 to 2010
$1.6M
Dimension Reduction Approaches for Genome-wide Association TestingU01HL084706 · NHLBI · CORNELL UNIVERSITY · PI CLARK, ANDREW G · 2006 to 2008
$921k
NHGRI NIH HHS HG002790NHGRI NIH HHS P50 HG002790NHLBI NIH HHS HL084706NHLBI NIH HHS U01 HL084706NIGMS NIH HHS GM069890NIGMS NIH HHS GM67243NIGMS NIH HHS R01 GM067243NIGMS NIH HHS R01 GM069890NIMH NIH HHS MH084678NIMH NIH HHS R01 MH084678
6 · The paper itself

Abstract

This article is concerned with statistical modeling of shotgun resequencing data and the use of such data for population genetic inference. We model data produced by sequencing-by-synthesis technologies such as the Solexa, 454, and polymerase colony (polony) systems, whose use is becoming increasingly widespread. We show how such data can be used to estimate evolutionary parameters (mutation and recombination rates), despite the fact that the data do not necessarily provide complete or aligned sequence information. We also present two refinements of our methods: one that is more robust to sequencing errors and another that can be used when no reference genome is available.

Indexed as

Genetics, PopulationDiploidyGenome, HumanHomozygoteHumansLinkage DisequilibriumPolymorphism, Single NucleotideSequence Analysis, DNA

Identifiers

PMID18984575
PMCPMC2621167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.