ArticleHeart rhythm2008
Electrophysiological mechanisms of antiarrhythmic protection during hypothermia in winter hibernating versus nonhibernating mammals.
Article in Heart rhythm, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- A cross species thermoelectric and spatiotemporal analysis of alternans in live explanted hearts using dual voltage-calcium fluorescence optical mapping.Physiological measurement · 2024Article
- Beneficial Electrophysiological Effects of Rotigaptide Are Unable to Suppress Therapeutic Hypothermia-Provoked Ventricular Fibrillation in Failing Rabbit Hearts With Acute Ischemia-Reperfusion Injury.Frontiers in physiology · 2021Article
- Defibrillate You Later, Alligator: Q10 Scaling and Refractoriness Keeps Alligators from Fibrillation.Integrative organismal biology (Oxford, England) · 2021Article
- Therapeutic Hypothermia Reduces Peritoneal Dialysis Induced Myocardial Blood Flow Heterogeneity and Arrhythmia.Frontiers in medicine · 2021Article
- Electrophysiological Characterization of Human Atria: The Understated Role of Temperature.Frontiers in physiology · 2021Article
- Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome.Frontiers in physiology · 2020Review
- Hypothermia-Induced Postrepolarization Refractoriness Is the Reason of the Atrial Myocardium Tolerance to the Bioelectrical Activity Disorders in the Hibernating and Active Ground Squirrel Citellus undulatus.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2019Article
- Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368.BMC anesthesiology · 2019Article
- Induction of hibernation-like hypothermia by central activation of the A1 adenosine receptor in a non-hibernator, the rat.The journal of physiological sciences : JPS · 2018Article
- Thermoregulation and energetics in hibernating black bears: metabolic rate and the mystery of multi-day body temperature cycles.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Article
- Myocardial ischemic protection in natural mammalian hibernation.Basic research in cardiology · 2015Article
- Proteomic mechanisms of cardioprotection during mammalian hibernation in woodchucks, Marmota monax.Journal of proteome research · 2013Article
- Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy.Circulation · 2012Article
- Elucidating nature's solutions to heart, lung, and blood diseases and sleep disorders.Circulation research · 2012Article
- Multistate proteomics analysis reveals novel strategies used by a hibernator to precondition the heart and conserve ATP for winter heterothermy.Physiological genomics · 2011Article
- Enhanced dispersion of repolarization explains increased arrhythmogenesis in severe versus therapeutic hypothermia.Circulation. Arrhythmia and electrophysiology · 2011Article
- Circulation and metabolic rates in a natural hibernator: an integrative physiological model.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Transmural dispersion of repolarization in failing and nonfailing human ventricle.Circulation research · 2010Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundRobust cell-to-cell coupling is critically important in the safety of cardiac conduction and protection against ventricular fibrillation (VF). Hibernating mammals have evolved naturally protective mechanisms against VF induced by hypothermia and reperfusion injury.
objectiveWe hypothesized that this protection strategy involves a dynamic maintenance of conduction and repolarization patterns through the improvement of gap junction functions.
methodsWe optically mapped the hearts of summer-active (SA) and winter-hibernating (WH) ground squirrels Spermophilus undulatus from Siberia and nonhibernating rabbits during different temperatures (+3 degrees C to +37 degrees C).
resultsMidhypothermia (+17 degrees C) resulted in nonuniform conduction slowing, increased dispersion of repolarization, shortened wavelength, and consequently enhanced VF induction in SA ground squirrels and rabbits. In contrast, wavelength was increased during hypothermia in WH hearts in which VF was not inducible at any temperature. In SA and rabbit hearts, but not in WH, conduction anisotropy was significantly increased by pacing acceleration, thus promoting VF induction during hypothermia. WH hearts maintained the same rate-independent anisotropic propagation pattern even at 3 degrees C. connexin 43 (Cx43) had more homogenous transmural distribution in WH ventricles as compared to SA. Moreover, Cx43 and N-cadherins (N-cad) densities as well as the percentage of their colocalization were significantly higher in WH compared to SA epicardium.
conclusionRate-independent conduction anisotropy ratio, low dispersion of repolarization, and long wavelength-these are the main electrophysiological mechanisms of antiarrhythmic protection in hibernating mammalian species during hypothermia. This strategy includes the improved gap junction function, which is due to overexpression and enhanced colocalization of Cx43 and N-cad.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.