ArticleRetrovirology2008
Intragenic transcriptional cis-activation of the human immunodeficiency virus 1 does not result in allele-specific inhibition of the endogenous gene.
Article in Retrovirology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Barriers for HIV Cure: The Latent Reservoir.AIDS research and human retroviruses · 2018Review
- Visual detection of Flavivirus RNA in living cells.Methods (San Diego, Calif.) · 2016Review
- HIV latency and integration site placement in five cell-based models.Retrovirology · 2013Article
- HIV-1 transcription and latency: an update.Retrovirology · 2013Review
- Human immunodeficiency virus (HIV) latency: the major hurdle in HIV eradication.Molecular medicine (Cambridge, Mass.) · 2012Review
- Article
- Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1.Journal of virology · 2012Article
- The viral protein Tat can inhibit the establishment of HIV-1 latency.Journal of virology · 2012Article
- Molecular Understanding of HIV-1 Latency.Advances in virology · 2012Article
- Fast transcription rates of RNA polymerase II in human cells.EMBO reports · 2011Article
- HIV latency.Cold Spring Harbor perspectives in medicine · 2011Review
- Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function.Retrovirology · 2011Article
- Chromatin reassembly factors are involved in transcriptional interference promoting HIV latency.Journal of virology · 2011Article
- Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies.Retrovirology · 2009Review
- Transcriptional competence of the integrated HIV-1 provirus at the nuclear periphery.The EMBO journal · 2009Article
- Suppression of HIV-1 replication by microRNA effectors.Retrovirology · 2009Article
- Nuclear positional control of HIV transcription in 4D.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe human immunodeficiency virus type 1 (HIV-1) favors integration in active genes of host chromatin. It is believed that transcriptional interference of the viral promoter over the endogenous gene or vice versa might occur with implications in HIV-1 post-integrative transcriptional latency.
resultsIn this work a cell line has been transduced with a HIV-based vector and selected for Tat-inducible expression. These cells were found to carry a single silent integration in sense orientation within the second intron of the HMBOX1 gene. The HIV-1 Tat transactivator induced the viral LTR and repressed HMBOX1 expression independently of vector integration. Instead, single-cell quantitative in situ hybridization revealed that allele-specific transcription of HMBOX1 carrying the integrated provirus was not affected by the transactivation of the viral LTR in cis.
conclusionA major observation of the work is that the HIV-1 genome has inserted in genes that are also repressed by Tat and this could be an advantage for the virus during transcriptional reactivation. In addition, it has also been observed that transcription of the provirus and of the endogenous gene in which it is integrated may coexist at the same time in the same genomic location.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.