ArticleThe Biochemical journal1991
Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II.
Article in The Biochemical journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Inside the Insulin Secretory Granule.Metabolites · 2021Review
- Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway.Molecular biology of the cell · 2003Article
- Chronic central neuropeptide Y infusion in normal rats: status of the hypothalamo-pituitary-adrenal axis, and vagal mediation of hyperinsulinaemia.Diabetologia · 1997Article
- Proinsulin processing in the rat insulinoma cell line INS after overexpression of the endoproteases PC2 or PC3 by recombinant adenovirus.The Biochemical journal · 1996Article
- Sequence requirements for proinsulin processing at the B-chain/C-peptide junction.The Biochemical journal · 1995Article
- Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.The American journal of pathology · 1995Article
- Review
- pH-independent and -dependent cleavage of proinsulin in the same secretory vesicle.The Journal of cell biology · 1994Article
- Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet beta cells and non-beta cells.The Biochemical journal · 1994Article
- Sorting and processing of secretory proteins.The Biochemical journal · 1994Review
- Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic beta cell.Diabetologia · 1991Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Rat proinsulin I is converted into insulin more rapidly than is proinsulin II. To study this further, rat islets were labelled (10 min) and conversion kinetics of the labelled proinsulins were monitored during a 120 min chase. Proinsulins, conversion intermediates and both insulins were separated by h.p.l.c. The accumulation of des-64,65-(split proinsulin II) during the chase suggests that the B-chain/C-peptide junction of proinsulin II is cleaved more slowly than the equivalent site on proinsulin I. This accounts for the differential kinetics of conversion of proinsulins I and II, and is presumed to be caused by one (or more) of the amino acid replacements which distinguish the two proinsulins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.