Evidence map›Paper›PMID 18983260›Full record

ReviewAnnual review of genetics2008

Molecular determinants of a symbiotic chronic infection.

Katherine E Gibson, Hajime Kobayashi, Graham C Walker

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed
37.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 353 citations in OpenAlex.

  1. BacA(SbmA) importer of legume symbiotic NCR peptides: Protein architecture, function, and evolutionary implications.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  4. WrtF fromProceedings of the National Academy of Sciences of the United States of America · 2025
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  5. Article
  6. Article
  7. Review
  8. TheJournal of bacteriology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Exopolysaccharide Biosynthesis inInternational journal of molecular sciences · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Katherine E GibsonDepartment of Biology, University of Massachusetts, Boston, Massachusetts 02125, USA.
Hajime Kobayashi
Graham C Walker
Massachusetts Institute of Technology · US

Funding

MOLEULAR GENETICS OF RHIZOBIUM PLASMIDSR01GM031030 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WALKER, GRAHAM C · 1985 to 2020
$8.6M
MUTAGENESIS AND REPAIR OF DNAR01CA021615 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WALKER, GRAHAM C · 1985 to 2019
$6.5M
NCI NIH HHS CA21615-27NCI NIH HHS R01 CA021615NIGMS NIH HHS GM31010NIGMS NIH HHS R01 GM031030
6 · The paper itself

Abstract

Rhizobial bacteria colonize legume roots for the purpose of biological nitrogen fixation. A complex series of events, coordinated by host and bacterial signal molecules, underlie the development of this symbiotic interaction. Rhizobia elicit de novo formation of a novel root organ within which they establish a chronic intracellular infection. Legumes permit rhizobia to invade these root tissues while exerting control over the infection process. Once rhizobia gain intracellular access to their host, legumes also strongly influence the process of bacterial differentiation that is required for nitrogen fixation. Even so, symbiotic rhizobia play an active role in promoting their goal of host invasion and chronic persistence by producing a variety of signal molecules that elicit changes in host gene expression. In particular, rhizobia appear to advocate for their access to the host by producing a variety of signal molecules capable of suppressing a general pathogen defense response.

Indexed as

Biological EvolutionCell CycleFabaceaeModels, BiologicalNitrogen FixationReactive Nitrogen SpeciesReactive Oxygen SpeciesRhizobiumSignal TransductionStress, PhysiologicalSymbiosisReactive Nitrogen SpeciesReactive Oxygen Species

Identifiers

PMID18983260
PMCPMC2770587
OpenAlexW2157614298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.